INT28314

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 12.56
Pain Relevance 13.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
neurons 8
spinal cord 4
covering 2
embryos 2
telencephalic 2
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 957 100.00 Very High Very High Very High
GABAergic 472 100.00 Very High Very High Very High
tetrodotoxin 16 100.00 Very High Very High Very High
lidocaine 8 100.00 Very High Very High Very High
antagonist 303 99.96 Very High Very High Very High
Spinal cord 124 99.56 Very High Very High Very High
Ventral tegmentum 20 99.22 Very High Very High Very High
Glutamate 122 98.66 Very High Very High Very High
Dopamine 202 98.60 Very High Very High Very High
hyperexcitability 16 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 34 100.00 Very High Very High Very High
Epilepsy 42 99.76 Very High Very High Very High
Anxiety Disorder 147 99.62 Very High Very High Very High
Sprains And Strains 48 99.58 Very High Very High Very High
Targeted Disruption 117 98.96 Very High Very High Very High
Status Epilepticus 4 98.52 Very High Very High Very High
Convulsion 122 98.40 Very High Very High Very High
Panic Disorder 4 98.32 Very High Very High Very High
Urological Neuroanatomy 4 96.60 Very High Very High Very High
Neuropathic Pain 168 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, neuroimaging studies have demonstrated a clear reduction of GABA levels in the occipital cortex of patients with panic disorders [13].
Spec (clear) Negative_regulation (reduction) of Gene_expression (levels) of GABA in occipital cortex associated with panic disorder and gaba
1) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 1.02 Pain Relevance 0.88
Haplotype analysis of one of the blocks in the GABA-A receptor ?
Negative_regulation (blocks) of Gene_expression (receptor) of GABA-A associated with gaba
2) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC2072938 Disease Relevance 0 Pain Relevance 0.20
On the other hand, bicuculline and picrotoxin antagonized not only GABA but also NE, whereas yohimbine counteracted not only NE but also GABA inhibition of ACh release, suggesting a close assembly of alpha-2 and GABAA receptors on the cholinergic axons.
Negative_regulation (close) of Gene_expression (assembly) of GABAA associated with gaba
3) Confidence 0.34 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3001287 Disease Relevance 0 Pain Relevance 0.34
In this case, the first peak of the ongoing PER2::LUC rhythms occurred ca. 14 h after the media change, not ca. 22 h after, as when GABA was washed out (n = 3).
Negative_regulation (as) of Gene_expression (washed) of GABA associated with gaba
4) Confidence 0.34 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.45
Additionally, glutamate decarboxylase 65 knockout mice displayed increased anxiety-like behavior and reduced GABA levels [14].
Negative_regulation (reduced) of Gene_expression (levels) of GABA associated with targeted disruption, gaba, glutamate and anxiety disorder
5) Confidence 0.32 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1766473 Disease Relevance 0.92 Pain Relevance 0.73
The most direct demonstration that GABAergic inhibition actively restricts plasticity in the adult visual cortex derives from the very recent report that a pharmacological reduction of inhibition obtained by intracortical infusion of either mercaptopropionic acid (MPA, an inhibitor of GABA synthesis) or picrotoxin (PTX, a GABAA receptor antagonist), at doses which do not alter visual cortical neuron responsiveness, reactivates OD plasticity in response to MD in adult rats (Harauzov et al., 2010) (Figure 2).
Negative_regulation (inhibitor) of Gene_expression (synthesis) of GABA in neuron associated with gaba, antagonist and gabaergic
6) Confidence 0.30 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2854574 Disease Relevance 0.14 Pain Relevance 0.17
Finally, an emergent approach in our laboratory is to examine methods to deplete elevated GABA and GHB levels in developing embryos.
Spec (examine) Negative_regulation (deplete) of Gene_expression (levels) of GABA in embryos associated with gaba
7) Confidence 0.27 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.27 Pain Relevance 0.19
Co-expression of BIG2 and the beta3 subunit results in the loss of the beta3-containing GABAA receptors from ER and Golgi.
Negative_regulation (loss) of Gene_expression (receptors) of GABAA
8) Confidence 0.27 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0
The pure inhibitory effects of the GABAA receptors later in development (between postnatal day 3 and?
Negative_regulation (effects) of Gene_expression (receptors) of GABAA
9) Confidence 0.27 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.36
Regulated endocytosis of GABAA receptors
Negative_regulation (endocytosis) of Gene_expression (receptors) of GABAA
10) Confidence 0.27 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.08
Constitutive endocytosis of GABAA receptors
Negative_regulation (endocytosis) of Gene_expression (receptors) of GABAA
11) Confidence 0.27 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.09 Pain Relevance 0.11
Interestingly, agents that blocked GABA synthesis caused a reduction of neurite outgrowth.
Negative_regulation (blocked) of Gene_expression (synthesis) of GABA in neurite associated with gaba
12) Confidence 0.27 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0.12 Pain Relevance 0.35
At the same time, chronic GABAergic depletion (by blockade of GABA synthesis) caused severe arbor shrinkage, but dendrites also exhibited numerous very small dendritic branches covering the entire dendritic tree (F.
Negative_regulation (blockade) of Gene_expression (synthesis) of GABA in covering associated with gaba and gabaergic
13) Confidence 0.27 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0.06 Pain Relevance 0.41
In support, tonic GABA currents were recorded in acute slices at ages at which forced expression of KCC2 or downregulation of NKCC1 affected neuritogenesis in newborn neurons both during development and in the adult animal, respectively (Ge et al., 2006; Cancedda et al., 2007).
Negative_regulation (downregulation) of Gene_expression (expression) of GABA in neurons associated with gaba
14) Confidence 0.27 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0.06 Pain Relevance 0.48
There is indirect evidence that also in this case the enhanced visual cortical plasticity may be related to a reduced expression of GABAA receptors relative to AMPA receptors.
Negative_regulation (reduced) of Gene_expression (expression) of GABAA
15) Confidence 0.25 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2854574 Disease Relevance 0 Pain Relevance 0.07
Results are as follows: (1) The expression of GABA in the NaSA and NaSA + lidocaine groups decreased remarkably compared with that in the control group; there was no noticeable difference between the NaSA and NaSA + lidocaine groups.
Negative_regulation (decreased) of Gene_expression (expression) of GABA associated with gaba and lidocaine
16) Confidence 0.20 Published 2006 Journal Sheng Li Xue Bao Section Abstract Doc Link 17041729 Disease Relevance 0 Pain Relevance 0.90
We found that differences in oscillation frequency between mouse strains may be explained by differences in GABAergic synapse properties and GABAA-receptor subunit expression.


Negative_regulation (differences) of Gene_expression (expression) of GABAA-receptor in synapse associated with gabaergic and sprains and strains
17) Confidence 0.20 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.42 Pain Relevance 0.22
GABRB1 mRNA is known to be downregulated by persistent GABAA receptor activation and in a model of temporal lobe epilepsy [28,29].
Negative_regulation (downregulated) of Gene_expression (activation) of GABAA receptor in temporal lobe associated with epilepsy
18) Confidence 0.18 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.26 Pain Relevance 0.44
Due to a loss of the glycine or the decreased synthesis or secretion of GABA, the blockage of receptors and a loss of inhibitory intermediate neurons, if a loss of the inhibitory function should occur in the posterior horn of spinal cord, i.e., disinhibition should occur, allodynia would occur.
Negative_regulation (loss) of Gene_expression (synthesis) of GABA in spinal cord associated with gaba, allodynia and spinal cord
19) Confidence 0.17 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872893 Disease Relevance 1.63 Pain Relevance 1.73
Due to a loss of the glycine or the decreased synthesis or secretion of GABA, the blockage of receptors and a loss of inhibitory intermediate neurons, if a loss of the inhibitory function should occur in the posterior horn of spinal cord, i.e., disinhibition should occur, allodynia would occur.
Negative_regulation (decreased) of Gene_expression (synthesis) of GABA in spinal cord associated with gaba, allodynia and spinal cord
20) Confidence 0.17 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872893 Disease Relevance 1.61 Pain Relevance 1.68

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