INT283142

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Context Info
Confidence 0.59
First Reported 2009
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tongue 1
taste bud 1
posterior 1
papillae 1
PKD1L3 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 138 96.44 Very High Very High Very High
ASIC 150 89.28 High High
Endep 24 5.00 Very Low Very Low Very Low
aspirin 12 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
lidocaine 12 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ageusia 96 50.00 Quite Low
Loss Of Sense Of Smell 42 5.00 Very Low Very Low Very Low
Polycystic Kidney Disease 30 5.00 Very Low Very Low Very Low
Aging 18 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Lower Respiratory Tract Infection 12 5.00 Very Low Very Low Very Low
Taste Disorders 6 5.00 Very Low Very Low Very Low
Critical Illness 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also not detected in the fungiform cDNA of Patient 8689 were the two channels, PKD1L3 and PKD2L1, even after 50 cycles of amplification (Figure 2, Lanes C and F).
Neg (not) Gene_expression (detected) of PKD1L3
1) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.09
Our RT-PCR results, wherein evidence of transcripts for both PKD2L1 and PKD1L3 was detected in human fungiform papillae of normal subjects (Figure 2), are consistent with our immunohistochemical results.
Gene_expression (detected) of PKD1L3 in papillae
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0
The latter data show only PKD2L1 in taste bud cells (Panel H) and PKD1L3 in areas of the fungiform papillae other than the taste bud cells (Panel I).
Gene_expression (show) of PKD1L3 in taste bud
3) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.03
The detection of PKD1L3 in human fungiform papillae (sour normal) is in contrast to results from rodents showing no expression of PKD1L3 in anterior tongue [16]–[18].
Neg (no) Gene_expression (expression) of PKD1L3 in tongue
4) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.08
On the other hand, rodents do express PKD1L3 in the posterior tongue.
Gene_expression (express) of PKD1L3 in posterior
5) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.09
Patient 8716 also did not express transcripts for PKD1L3 and PKD2L1 (Figure 2, Lanes D and G).
Neg (not) Gene_expression (express) of PKD1L3
6) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.30

General Comments

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