INT283146

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.64
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (TAS2R14)
Anatomy Link Frequency
papillae 1
TAS2R14 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 97.76 Very High Very High Very High
sodium channel 23 80.88 Quite High
alcohol 15 69.52 Quite High
ASIC 25 50.00 Quite Low
Endep 4 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Piles 3 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Weight Loss 6 92.64 High High
Colon Cancer 42 87.04 High High
Nicotine Addiction 51 70.48 Quite High
Ageusia 16 50.00 Quite Low
Toxicity 6 34.00 Quite Low
Cancer 12 32.56 Quite Low
Obesity 9 29.28 Quite Low
Loss Of Sense Of Smell 7 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several bitter substances that have been shown to activate TAS2R14 are powerful toxic agents like picrotoxin, which is an antagonist of GABAA-receptors leading to neurotoxic effects including convulsant action in human and rodents [7] and aristolochic acid, which is a strong carcinogen that nonetheless is used as an herbal remedy for weight loss.
Positive_regulation (activate) of TAS2R14 associated with weight loss and antagonist
1) Confidence 0.50 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2893173 Disease Relevance 0.09 Pain Relevance 0.05
Several substances that have been shown to activate TAS2R14 are powerful toxic and carcinogenic agents.


Positive_regulation (activate) of TAS2R14
2) Confidence 0.47 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2893173 Disease Relevance 0.27 Pain Relevance 0
TAS2R14 has been shown to be activated by various substances, several of which are powerful toxic agents like picrotoxin and aristolochic acid which is a strong carcinogen, that nonetheless is used as an herbal remedy for weight loss.
Positive_regulation (activated) of TAS2R14 associated with weight loss
3) Confidence 0.47 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2893173 Disease Relevance 0.27 Pain Relevance 0.06
2, which is expressed specifically in the taste bud (see below in the section entitled “Immunohistochemistry for putative taste-related proteins”), participates in the transduction pathways of both bitter and sweet receptors [37], while the bitter taste receptor T2R14, which is activated by multiple bitter compounds [38] is, in our experience, relatively abundant in human fungiform papillae.
Positive_regulation (activated) of T2R14 in papillae
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.07

General Comments

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