INT28315

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 1989
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 4.78
Pain Relevance 7.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
postsynaptic membrane 4
neuronal 2
choroid plexus 2
neurons 2
oocytes 2
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 254 100.00 Very High Very High Very High
antagonist 15 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
tetrodotoxin 5 99.92 Very High Very High Very High
Ventral tegmentum 8 99.68 Very High Very High Very High
agonist 30 99.08 Very High Very High Very High
opioid receptor 8 98.86 Very High Very High Very High
GABAergic 109 97.88 Very High Very High Very High
TRP channel 6 97.84 Very High Very High Very High
Spinal cord 53 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 58 99.76 Very High Very High Very High
Convulsion 87 98.88 Very High Very High Very High
Targeted Disruption 69 97.70 Very High Very High Very High
Status Epilepticus 57 96.04 Very High Very High Very High
Opiate Addiction 1 95.48 Very High Very High Very High
Autoimmune Disease 67 93.44 High High
Cleft Palate 12 85.68 High High
Syndrome 122 84.24 Quite High
Epilepsy 57 83.80 Quite High
Death 7 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The alterations in the expression of several GABAA receptor subunits and that of CB1 may, on the other hand, be of importance for seizure regulation.
Regulation (alterations) of Gene_expression (expression) of GABAA associated with convulsion
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.79 Pain Relevance 0.32
Second, subunit composition specifically affects the dynamic control of GABAA receptor expression at the cell surface and may thus effectively determine its presence at the postsynaptic membrane ([36-39]; see for review also [40].
Regulation (affects) of Gene_expression (expression) of GABAA receptor in postsynaptic membrane
2) Confidence 0.47 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1544347 Disease Relevance 0 Pain Relevance 0.06
Cis-4-aminocrotonic acid (CACA), a specific GABA(C) receptor agonist, induced an inhibitory effect, consisting in the reduction of the amplitude of the spontaneous contractions and muscular relaxation, which was antagonised by TPMPA, GABA(C)-receptor antagonist, TTX or N(omega)-nitro-l-arginine methyl ester (L-NAME), nitric oxide (NO) synthase inhibitor, but not affected by hexamethonium.
Regulation (antagonised) of Gene_expression (antagonist) of GABA associated with tetrodotoxin, gaba, antagonist and agonist
3) Confidence 0.33 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17517423 Disease Relevance 0 Pain Relevance 1.15
Apart from the direct regulation of receptor function by the phosphorylation state, the PRIP protein family (PRIP-1 and PRIP-2) is also involved in GABAA receptor endocytosis, which is another factor to regulate synaptic inhibition (Kanematsu, 2007, see below).
Regulation (involved) of Gene_expression (endocytosis) of GABAA receptor
4) Confidence 0.29 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.12 Pain Relevance 0.13
Interacting proteins involved in GABAA receptor trafficking
Regulation (involved) of Gene_expression (trafficking) of GABAA receptor
5) Confidence 0.29 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0 Pain Relevance 0.09
Effects of A1R manipulation on island rhythmogenesis during GABAA receptor antagonism
Regulation (Effects) of Gene_expression (antagonism) of GABAA receptor
6) Confidence 0.22 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0 Pain Relevance 0
Second, subunit composition specifically affects the dynamic control of GABAA receptor expression at the cell surface and may thus effectively determine its presence at the postsynaptic membrane ([36-39]; see for review also [40].
Regulation (control) of Gene_expression (expression) of GABAA receptor in postsynaptic membrane
7) Confidence 0.21 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1544347 Disease Relevance 0 Pain Relevance 0.06
We observed modest evidence of association (P = 0.05) between BI and the glutamic acid decarboxylase gene (65 kDA isoform), which encodes an enzyme involved in GABA synthesis.
Regulation (involved) of Gene_expression (synthesis) of GABA associated with gaba
8) Confidence 0.20 Published 2001 Journal Am. J. Med. Genet. Section Abstract Doc Link 11353440 Disease Relevance 0.21 Pain Relevance 0.14
Coupled with changes in GABRB1 in COX-2-/- mice, we also demonstrated an alteration in the expression of a GABA transporter.
Regulation (alteration) of Gene_expression (expression) of GABA associated with gaba
9) Confidence 0.19 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.26 Pain Relevance 0.48
GABA transporter and receptor expression is altered in COX-/- mice
Regulation (altered) of Gene_expression (expression) of GABA associated with gaba
10) Confidence 0.19 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.09 Pain Relevance 0.45
Here we examine the role of micro-opioid receptor (MOR) trafficking in one of these adaptations, specifically, changes in GABA transmission in the ventral tegmental area (VTA).
Spec (examine) Regulation (changes) of Gene_expression (transmission) of GABA in ventral associated with ventral tegmentum, gaba and opioid receptor
11) Confidence 0.18 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20203187 Disease Relevance 0.30 Pain Relevance 1.38
Altered expression of GABA neurotransmission genes in COX-1-/- and COX-2-/- mice
Regulation (Altered) of Gene_expression (expression) of GABA associated with gaba
12) Confidence 0.11 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.26 Pain Relevance 0.26
The net effect of the alterations in GABA-related gene expression in the COX-2-/- mouse brain would suggest decreased GABAergic tone, predisposing these mice to an increased neuronal excitability that would increase their susceptibility to excitotoxins such as kainate.
Regulation (effect) of Gene_expression (expression) of GABA-related gene in neuronal associated with gaba, neuronal excitability and gabaergic
13) Confidence 0.11 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.17 Pain Relevance 0.45
There is a lower expression of GABA receptors in the fragile X knock out (KO) mouse (DÂ’Hulst et al. 2006) and an increased expression of glutamic acid decarboxylase (GAD), the enzyme responsible for GABA synthesis in the KO mouse (El Idrissi et al. 2005).
Regulation (responsible) of Gene_expression (synthesis) of GABA associated with targeted disruption, gaba, generalized anxiety disorder and gaba receptor
14) Confidence 0.10 Published 2010 Journal Hum Genet Section Body Doc Link PMC2955238 Disease Relevance 1.53 Pain Relevance 0.21
The GABA release produced by toxic peptide NTX1-9 was not affected by tetrodotoxin but was completely abolished by the presence of the K+ ionophore valinomycin, mimicking the effect of native NTX in the same system (Sitges et al., 1986).
Neg (not) Regulation (affected) of Gene_expression (produced) of GABA associated with tetrodotoxin and gaba
15) Confidence 0.09 Published 1989 Journal J. Neural Transm. Section Abstract Doc Link 2746197 Disease Relevance 0 Pain Relevance 0.20
Despite the expression of AMPA, NMDA, GABA, opioid and adrenergic receptors on cultured microglia [7-11], the present study showed no effect of different receptor agonists on the resting microglia in acute spinal cord slices.
Neg (no) Regulation (effect) of Gene_expression (expression) of GABA in microglia associated with gaba, agonist, opioid and spinal cord
16) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.20 Pain Relevance 0.58
Bond et al. [27] showed that GAD25 is expressed in a temporally controlled manner, in the developing striatum and cortex in rodents, suggesting this may provide a mechanism of regulating GABA production in differentiating neurons.
Regulation (regulating) of Gene_expression (production) of GABA in neurons associated with gaba
17) Confidence 0.04 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.25 Pain Relevance 0.34
The possible expression of GABAA receptors in the choroid plexus, however, has not been substantiated by molecular or electrophysiological methods.

3.2.6 TRP channels

Neg (not) Regulation (substantiated) of Gene_expression (expression) of GABAA in choroid plexus associated with trp channel
18) Confidence 0.04 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0 Pain Relevance 0.14
We tested the abilities of enflurane and five of these compounds to potentiate gamma-aminobutyric acid (GABA)A receptor responses in Xenopus oocytes expressing alpha 1 beta 2 or alpha 1 beta 2 gamma 2S GABAA receptors.
Regulation (responses) of Gene_expression (expressing) of GABAA in oocytes associated with gaba
19) Confidence 0.03 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 7969071 Disease Relevance 0 Pain Relevance 0.32
S(12)C amino acid substitution may thus produce subtle effects on cellular localisation, protein-protein interactions and/or protein processing, with a subsequent effect on GABA production.
Regulation (effect) of Gene_expression (production) of GABA associated with gaba
20) Confidence 0.02 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.49 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox