INT28320

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Context Info
Confidence 0.58
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 5.69
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Abo) Golgi apparatus (Abo) carbohydrate metabolic process (Abo)
Anatomy Link Frequency
hepatocytes 1
1A2 1
astrocytes 1
hearts 1
Abo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 52 100.00 Very High Very High Very High
Dopamine 4 100.00 Very High Very High Very High
monoamine 1 100.00 Very High Very High Very High
opiate 2 99.98 Very High Very High Very High
noradrenaline 10 99.16 Very High Very High Very High
Glutamate 2 98.92 Very High Very High Very High
Paracetamol 28 98.84 Very High Very High Very High
withdrawal 5 97.36 Very High Very High Very High
Analgesic 2 97.24 Very High Very High Very High
Clonidine 6 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Recurrence 1 100.00 Very High Very High Very High
Mitochondrial Myopathies 3 99.92 Very High Very High Very High
Muscle Disease 8 99.76 Very High Very High Very High
Ventricular Fibrillation 7 99.06 Very High Very High Very High
Glycogen Storage Disease 1 98.88 Very High Very High Very High
Toxicity 8 98.28 Very High Very High Very High
Disease 5 97.88 Very High Very High Very High
Rhabdomyolysis 4 97.58 Very High Very High Very High
Central Core Disease 1 97.36 Very High Very High Very High
Syndrome 3 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of inhibition of conjugation by flavonoids in cultured hepatocytes is not likely to depend on the direct inhibition of sulfo- and glucurono-transferase activity by flavonoids.
Negative_regulation (inhibition) of glucurono-transferase in hepatocytes
1) Confidence 0.58 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15133252 Disease Relevance 0 Pain Relevance 0.21
After the peak activities were reached, there was a continuous decrease in the glucuronyl transferase activities.
Negative_regulation (decrease) of transferase
2) Confidence 0.43 Published 1981 Journal Dev Pharmacol Ther Section Abstract Doc Link 6802622 Disease Relevance 0 Pain Relevance 0.16
A new model of ventricular fibrillation induced by isoprenaline and catechol-O-methyl transferase inhibitor at a high perfusion temperature in isolated rat hearts.
Negative_regulation (inhibitor) of transferase in hearts associated with ventricular fibrillation
3) Confidence 0.38 Published 1985 Journal J Pharmacol Methods Section Title Doc Link 4079442 Disease Relevance 0.45 Pain Relevance 0.07
Oral acamprosate 1.3 or 2 g/day in 3 divided doses administered for 3 to 12 months to alcohol-dependent patients after detoxification was more effective than placebo in preventing alcohol relapse according to abstinence rates, duration of abstinence, gamma-glutamyl transferase levels and/or a variety of other clinical or biological end-points.
Negative_regulation (preventing) of transferase associated with recurrence and alcohol
4) Confidence 0.37 Published 1997 Journal Drugs Section Abstract Doc Link 9179530 Disease Relevance 0.32 Pain Relevance 0.41
This was accompanied by a decrease in the dopamine-beta-hydroxylase and phenylethanolamine-N-methyl transferase activities of the A1/C1 region.
Negative_regulation (decrease) of transferase associated with dopamine
5) Confidence 0.29 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2869960 Disease Relevance 0.31 Pain Relevance 0.87
In many of these cases biopsy investigations do disclose, out of rhabdomyolysis, a preexistent myopathy, usually dysmetabolic in origin, and often with familial incidence (lipid myopathies; carnitine palmityl-transferase deficiency; mitochondrial myopathies; glycogenoses; hypokaliaemia--but also central core diseases, tubular aggregates myopathy a.s.o.).
Negative_regulation (deficiency) of palmityl-transferase associated with mitochondrial myopathies, glycogen storage disease, muscle disease, rhabdomyolysis and central core disease
6) Confidence 0.27 Published 1983 Journal Fortschr Neurol Psychiatr Section Abstract Doc Link 6642396 Disease Relevance 1.59 Pain Relevance 0.11
In the presence of inhibitors of the enzymes monoamine oxidase and catechol-O-methyl transferase, it was found that astrocytes took up noradrenaline by a temperature-dependent, sodium-independent mechanism that was saturable with a Km = 3.4 x 10(-7) M and a Vmax = 1.6 pmole/mg protein/2 min.
Negative_regulation (inhibitors) of transferase in astrocytes associated with noradrenaline and monoamine
7) Confidence 0.26 Published 1989 Journal J. Neurosci. Res. Section Abstract Doc Link 2746699 Disease Relevance 0 Pain Relevance 0.45
A genetic deficiency of bilirubin UDP-glucuronyl transferase (GT) occurs in 5 to 7% of the population (Gilbert's disease, Crigler-Najjar syndrome) and this could predispose such people to acetaminophen hepatotoxicity.
Negative_regulation (deficiency) of transferase associated with paracetamol, syndrome, hepatotoxicity and disease
8) Confidence 0.21 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3139868 Disease Relevance 0.36 Pain Relevance 0.43
Deficiency in bilirubin UDP-glucuronyl transferase as a genetic determinant of acetaminophen toxicity.
Negative_regulation (Deficiency) of transferase associated with toxicity and paracetamol
9) Confidence 0.15 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 3139868 Disease Relevance 0.35 Pain Relevance 0.56
Acetaminophen induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP), lipid peroxidase (LPO) with a reduction of total protein, superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione S-transferase (GST).
Negative_regulation (reduction) of transferase associated with glutamate and paracetamol
10) Confidence 0.11 Published 2008 Journal Pak J Pharm Sci Section Abstract Doc Link 18166521 Disease Relevance 0.16 Pain Relevance 0.45
These results suggest that the GalNAc transferase activity is regulated in more than one way during the cell cycle, since both Vmax and Km changes are observed, and that the cyclic AMP-dependent mechanism by which opiates reduce transferase activity is receptor mediated and cell cycle dependent.
Negative_regulation (reduce) of transferase associated with opiate
11) Confidence 0.09 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6422000 Disease Relevance 0 Pain Relevance 0.37
In this mouse model, betaine feeding prevented the changes in gene expression and the alterations in methionine metabolism by preventing a decrease in betaine homocysteine methyl transferase (BHMT) and glycine N methyl transferase [9].
Negative_regulation (decrease) of transferase
12) Confidence 0.06 Published 2010 Journal Genes Nutr Section Body Doc Link PMC2988994 Disease Relevance 0.51 Pain Relevance 0.26
In this mouse model, betaine feeding prevented the changes in gene expression and the alterations in methionine metabolism by preventing a decrease in betaine homocysteine methyl transferase (BHMT) and glycine N methyl transferase [9].
Negative_regulation (decrease) of transferase
13) Confidence 0.06 Published 2010 Journal Genes Nutr Section Body Doc Link PMC2988994 Disease Relevance 0.50 Pain Relevance 0.26
Treated groups exhibited a significant decrease in the levels of glucose-6-phosphatase (Fig. 4) and alanine amino transferase (Fig. 5).
Negative_regulation (decrease) of alanine amino transferase
14) Confidence 0.03 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193540 Disease Relevance 0.44 Pain Relevance 0
In carnitine palmityl transferase deficiency (under non-fasting conditions) VO2max is normal.
Negative_regulation (deficiency) of palmityl transferase
15) Confidence 0.03 Published 1984 Journal Med Sci Sports Exerc Section Abstract Doc Link 6595492 Disease Relevance 0.70 Pain Relevance 0.08
It is a potent inhibitor of CYP3A4, and a lesser inhibitor of CYP2D6.12 On the other hand, it is an inducer of several cytochromes P450, including 1A2, 2B6, 2C9, and 2C19, as well as glucuronyl transferase.16 Therefore, there is significant potential for drug–drug interactions.
Negative_regulation (inhibitor) of transferase in 1A2
16) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724190 Disease Relevance 0 Pain Relevance 0
With respect to management, two patients were simply observed, undergoing serial neuroimaging studies; two patients underwent biopsy sampling of their plexiform lesions; two patients underwent attempted medical treatment (farnesyl transferase inhibitor, R11577, and cyclophosphamide chemotherapy); and three patients required surgical debulking of their PNs because the massive growth of these tumors caused functional compromise.
Negative_regulation (inhibitor) of farnesyl transferase
17) Confidence 0.00 Published 2007 Journal J. Neurosurg. Section Body Doc Link 17566202 Disease Relevance 0 Pain Relevance 0

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