INT283243

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Context Info
Confidence 0.30
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.65
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfb) extracellular space (Vegfb) extracellular region (Vegfb)
intracellular (Vegfb)
Anatomy Link Frequency
corneas 1
Vegfb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 39 86.60 High High
cytokine 6 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Keratitis 84 88.12 High High
INFLAMMATION 45 86.60 High High
Corneal Neovascularization 60 76.40 Quite High
Infection 15 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Candida Infection 6 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 5 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 5 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Corneal Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF-B was downregulated -2.8 fold (p=0.002).
Negative_regulation (downregulated) of VEGF-B
1) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2756518 Disease Relevance 0.31 Pain Relevance 0.12
VEGF-B and VEGF-D were slightly downregulated at day 1 p.i., and VEGF-B remained relatively downregulated in infected corneas on day 3 p.i.
Negative_regulation (downregulated) of VEGF-B in corneas
2) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2756518 Disease Relevance 0.22 Pain Relevance 0
VEGF-B was downregulated -2.5 fold (p=0.04), and VEGF-D was downregulated -3.9 fold (p=0.0004) on day 1 p.i.
Negative_regulation (downregulated) of VEGF-B
3) Confidence 0.30 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2756518 Disease Relevance 0.12 Pain Relevance 0.06
By itself, it was not sufficient to simply switch the splicing but resulted in inhibition of VEGF165b without increased VEGF165.
Negative_regulation (inhibition) of VEGF165b
4) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0

General Comments

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