INT283244

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Context Info
Confidence 0.52
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 2.41
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pgf) extracellular space (Pgf) extracellular region (Pgf)
Anatomy Link Frequency
eyes 1
endothelial cells 1
corneas 1
Pgf (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 33 95.00 High High
antagonist 33 58.36 Quite High
cytokine 10 58.04 Quite High
fibrosis 5 55.80 Quite High
Inflammation 39 53.64 Quite High
medulla 2 6.04 Low Low
adenocard 6 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Corneal Neovascularization 61 93.28 High High
Fibromyalgia 1 93.04 High High
Candida Infection 6 91.24 High High
Targeted Disruption 13 89.60 High High
Cancer 37 87.80 High High
Alopecia 3 82.96 Quite High
Female Infertility 3 82.08 Quite High
Solid Tumor 8 80.08 Quite High
Keratitis 84 79.04 Quite High
Pancreatitis 3 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primers specific for VEGF-A, VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF) transcripts (Applied Biosystems) were used to quantify gene expression levels.
Gene_expression (expression) of PlGF
1) Confidence 0.52 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2756518 Disease Relevance 0 Pain Relevance 0
Compared to normal eyes, mock-inoculated controls were not significantly different in VEGF-A, VEGF-B, VEGF-C, VEGF-D, or PlGF expression levels.


Gene_expression (expression) of PlGF in eyes
2) Confidence 0.46 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2756518 Disease Relevance 0.12 Pain Relevance 0.03
Real-time reverse transcriptase polymerase chain reaction (RT-PCR) determined levels of genes encoding VEGF-A, VEGF-B, VEGF-C, and VEGF-D and placental growth factor in infected, mock-inoculated, and normal corneas.
Spec (determined) Gene_expression (levels) of placental growth factor in corneas
3) Confidence 0.46 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2756518 Disease Relevance 0.65 Pain Relevance 0
q cross-talk via AC3, such that siRNA knockdown of the AC3 isoform completely inhibited the potentiation of Butaprost-stimulated SAT1 expression by PGF.
Gene_expression (expression) of PGF
4) Confidence 0.33 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.70 Pain Relevance 0.03
inhibitor U73122 (10 µM) abolished the augmentation shown by PGF demonstrating this G?
Gene_expression (demonstrating) of PGF
5) Confidence 0.33 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.24
M Butaprost alone or with PGF (10? 
Gene_expression (with) of PGF
6) Confidence 0.33 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
A cell proliferation assay was performed on pGF, mGF and TTF cultures with identical passage numbers.
Gene_expression (cultures) of pGF
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
After expansion, 5 clones (3 from pGF cultures and 2 from mGF cultures: Fig. 1E) displaying proliferation and morphology characteristic of ES cells (Fig. 1G) were selected.
Gene_expression (cultures) of pGF
8) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939066 Disease Relevance 0 Pain Relevance 0
VEGFR-1 (ligands include VEGF-A, -B, and placental growth factor [PIGF]) and VEGFR-2 (ligands include VEGF-A, -C, and -D) are predominantly expressed on vascular endothelial cells, and activation of VEGFR-2 appears to be both necessary and sufficient to mediate VEGF-dependent angiogenesis and induction of vascular permeability [13, 14].
Gene_expression (expressed) of placental growth factor in endothelial cells
9) Confidence 0.10 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 0.95 Pain Relevance 0.03

General Comments

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