INT28336

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 37
Total Number 42
Disease Relevance 20.94
Pain Relevance 25.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pax3) nucleus (Pax3) DNA binding (Pax3)
Anatomy Link Frequency
nerves 5
neurons 4
bladder 3
dorsal 2
colon 2
Pax3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 1515 100.00 Very High Very High Very High
Pain 214 100.00 Very High Very High Very High
Glutamate 119 100.00 Very High Very High Very High
nav1.8 65 100.00 Very High Very High Very High
Neuropeptide 63 100.00 Very High Very High Very High
calcitonin gene related peptide 15 100.00 Very High Very High Very High
Calcitonin gene-related peptide 15 100.00 Very High Very High Very High
bradykinin 10 100.00 Very High Very High Very High
Nerve growth factor 125 99.96 Very High Very High Very High
Inflammation 781 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 204 100.00 Very High Very High Very High
INFLAMMATION 807 99.80 Very High Very High Very High
Nociception 119 99.74 Very High Very High Very High
Inflammatory Bowel Disease 497 99.72 Very High Very High Very High
Cystitis 64 99.58 Very High Very High Very High
Glucose Metabolism Disorders 4 99.40 Very High Very High Very High
Asthma 6 99.36 Very High Very High Very High
Ganglion Cysts 62 99.20 Very High Very High Very High
Disease 202 98.86 Very High Very High Very High
Incontinence 4 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the long-term effects of the N-terminus of SP on putative nociceptive transmitters, we investigated changes in formalin-induced nociception following an accumulation of SP N-terminal metabolites in mice.
Spec (investigated) Positive_regulation (accumulation) of SP associated with nociception and substance p
1) Confidence 0.33 Published 1996 Journal Pain Section Abstract Doc Link 8951939 Disease Relevance 0.51 Pain Relevance 0.73
Immunosuppressed mice infected with C. parvum demonstrated increased SP levels as well as physiological alterations (glucose malabsorption), weight loss, fecal oocyst shedding, and structural alterations (increased intestinal villi blunting) compared to uninfected mice.
Positive_regulation (increased) of SP in intestinal villi associated with weight loss, glucose metabolism disorders and substance p
2) Confidence 0.25 Published 2008 Journal J. Parasitol. Section Abstract Doc Link 18576802 Disease Relevance 0.85 Pain Relevance 0.53
Substance P (SP), a neuropeptide and pain transmitter, is associated with the gastrointestinal tract and is elevated in humans and macaques after experimental C. parvum challenge.
Positive_regulation (elevated) of SP associated with pain, neuropeptide and substance p
3) Confidence 0.25 Published 2008 Journal J. Parasitol. Section Abstract Doc Link 18576802 Disease Relevance 1.13 Pain Relevance 0.45
Taken together, these results demonstrate that increases of SP can drive inhibitory activity in the dorsal horn of spinal cord.
Positive_regulation (increases) of SP in spinal cord associated with dorsal horn, spinal cord and substance p
4) Confidence 0.20 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.33 Pain Relevance 1.25
The other issue is the molecular mechanism for SP induction of interneuronal excitability.
Positive_regulation (induction) of SP associated with substance p
5) Confidence 0.20 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.17 Pain Relevance 0.62
From P0 to P21, VIP fibers rapidly increased in number, but SP and CGRP fibers increased only slightly.
Positive_regulation (increased) of SP associated with calcitonin gene-related peptide and substance p
6) Confidence 0.16 Published 1996 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8873984 Disease Relevance 0 Pain Relevance 0.81
Using a knockout strategy, we have also raised mice with a deletion of the preprotachykinin-A (PPT-A) gene, which encodes for SP and neurokinin A (NKA), and have identified a specific behavioral phenotype in which the animals do not detect a window of "pain" intensities; this window cuts across stimulus modalities.
Positive_regulation (encodes) of SP associated with targeted disruption, pain and substance p
7) Confidence 0.16 Published 1999 Journal Reg Anesth Pain Med Section Abstract Doc Link 9952097 Disease Relevance 1.09 Pain Relevance 1.06
We observed that primary afferent stimulation recruiting C-fibers was required for both SP and BDNF release and ERK activation in post-synaptic dorsal horn neurons.
Positive_regulation (activation) of SP in neurons associated with c fibre, dorsal horn neuron and substance p
8) Confidence 0.16 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 14572451 Disease Relevance 0 Pain Relevance 0.92
These results suggest roles for SP, NKB, EXON-4-related peptide and histamine in sensory processing and transmission.
Positive_regulation (roles) of SP
9) Confidence 0.16 Published 1989 Journal Peptides Section Abstract Doc Link 2748424 Disease Relevance 0.23 Pain Relevance 0.13
RESULTS: NGF injected into the lower airway was able to induce SP (13.0+/-2.03% vs. 5.9+/-0.33%) and trkA expression (78+/-2.66% vs. 60+/-2.11%) in larger diameter (>25 microm), capsaicin-insensitive and trkA-positive vagal sensory neurons that were retrograde-labelled with Fast Blue dye from the main stem bronchi.
Positive_regulation (induce) of SP in stem
10) Confidence 0.14 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15347383 Disease Relevance 0 Pain Relevance 0
BACKGROUND: Nerve growth factor (NGF) is elevated in allergic diseases such as bronchial asthma and can lead to an induction of substance P (SP) and related neuropeptides in guinea-pigs large-diameter, neurofilament-positive airway neurons.
Positive_regulation (induction) of SP in Nerve associated with asthma, nerve growth factor, hypersensitivity, neuropeptide, disease and substance p
11) Confidence 0.14 Published 2004 Journal Clin. Exp. Allergy Section Abstract Doc Link 15347383 Disease Relevance 0.30 Pain Relevance 0.30
CONCLUSION: Based on the extent of SP and trkA co-expression in airway-specific neurons by NGF treatment, the present study suggests that, following a peripheral activation of trkA receptor on SP afferent by NGF which is elevated in allergic inflammation, there may be trkA-mediated SP induction to mediate neurogenic airway inflammation.


Positive_regulation (induction) of SP in neurons
12) Confidence 0.14 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15347383 Disease Relevance 0 Pain Relevance 0
This study portrays SP as a double-edged sword for pain transmission, SP's actions may depend both on the location of release (lamina I vs lamina V) and an the type of neuron it synapses with (projection neurons vs inhibitory neurons).


Positive_regulation (portrays) of SP in neuron associated with pain, projection neuron and substance p
13) Confidence 0.14 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.52 Pain Relevance 1.70
In contrast to PPD, SP and PPE in the dorsal and ventral striatum of mGluR1 mutant mice were elevated to a similar level as that of wild-type mice.
Positive_regulation (elevated) of SP in ventral associated with substance p
14) Confidence 0.14 Published 2002 Journal Synapse Section Abstract Doc Link 11891880 Disease Relevance 0 Pain Relevance 0.38
Third, exogenously applied SP- or stimulation-induced increases of sIPSCs were abolished in NK1R knockout (NK1R-/-) mice.
Positive_regulation (increases) of SP associated with targeted disruption and substance p
15) Confidence 0.13 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.30 Pain Relevance 1.31
- and C- fibers, induces the release of both glutamate and SP, mainly in lamina I and V.
Positive_regulation (induces) of SP in lamina associated with glutamate and substance p
16) Confidence 0.13 Published 2005 Journal Mol Pain Section Body Doc Link PMC1315348 Disease Relevance 0.43 Pain Relevance 1.13
We found that NGF, SP, and calcitonin gene-related peptide gene expression is upregulated in the dorsal root ganglion (DRG) of db/db mice before or during the period that they develop mechanical allodynia.
Positive_regulation (upregulated) of SP in DRG associated with ganglion cysts, dorsal root ganglion, allodynia, nerve growth factor and calcitonin gene-related peptide
17) Confidence 0.12 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19816194 Disease Relevance 1.26 Pain Relevance 1.09
Exposure to LPS increased the levels of TNF-alpha, SP and NGF production compared with controls (each p <0.05).
Positive_regulation (increased) of SP
18) Confidence 0.11 Published 2005 Journal J. Urol. Section Body Doc Link 15643278 Disease Relevance 0.15 Pain Relevance 0
In conclusion, based on the extent of SP and VR1 co-localization in nasal afferent neurons, the present study suggests that, following a peripheral activation of the VR1 receptor on SP afferents, there could be a triggering of SP-mediated phenomena, including those related to inflammation, such as plasma extravasation.
Positive_regulation (activation) of SP in plasma associated with inflammation
19) Confidence 0.09 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12906843 Disease Relevance 0.15 Pain Relevance 0.43
We found that acute injection of SKF-82958 increased preprodynorphin (PPD), substance P (SP), and preproenkephalin (PPE) mRNAs in the dorsal and ventral striatum of mutant and wild-type mice in a dose-dependent manner (0.125, 0.5, and 2 mg/kg, i.p.) as revealed by quantitative in situ hybridization.
Positive_regulation (increased) of SP in dorsal associated with substance p
20) Confidence 0.08 Published 2002 Journal Synapse Section Abstract Doc Link 11891880 Disease Relevance 0 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox