INT283399

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2009
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 5.48
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcn2) transport (Lcn2) extracellular space (Lcn2)
extracellular region (Lcn2)
Anatomy Link Frequency
respiratory 2
nasopharynx 1
Lcn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 288 99.48 Very High Very High Very High
Inflammatory response 108 91.60 High High
chemokine 144 89.08 High High
anesthesia 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacillus Anthracis Infection 18 100.00 Very High Very High Very High
INFLAMMATION 396 99.48 Very High Very High Very High
Pneumonia 198 97.56 Very High Very High Very High
Bacterial Infection 18 91.44 High High
Infection 144 90.64 High High
Lower Respiratory Tract Infection 18 85.92 High High
Sepsis 54 85.64 High High
Bacteremia 36 85.20 High High
Hemophilus Infection 18 85.12 High High
Sprains And Strains 288 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pathogens such as Klebsiella pneumoniae often produce additional siderophores [9],[10] that Lcn2 is not predicted to bind [11].
Lcn2 Binding (bind) of
1) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.27 Pain Relevance 0.12
This cluster encodes the Ent glycosylase IroB that prevents Lcn2 binding, and IroC to export, IroN to import, and IroD to linearize glycosylated Ent [18],[19].
Lcn2 Binding (binding) of
2) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.45 Pain Relevance 0.11
Lcn2 binds bacillibactin of Bacillus anthracis, but B. anthracis also produces the unusual siderophore petrobactin that Lcn2 cannot bind [32].
Lcn2 Binding (binds) of associated with bacillus anthracis infection
3) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.34 Pain Relevance 0.04
Consistent with the observation that expression of the iroA locus prevents Lcn2 binding, Lcn2 does not stimulate IL-8 release from cultured respiratory cells in response to Gly-Ent.


Lcn2 Binding (binding) of in respiratory
4) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.20 Pain Relevance 0.07
Lcn2 binds bacillibactin of Bacillus anthracis, but B. anthracis also produces the unusual siderophore petrobactin that Lcn2 cannot bind [32].
Lcn2 Binding (binds) of associated with bacillus anthracis infection
5) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.35 Pain Relevance 0.04
As a countermeasure, pathogens of the Enterobacteriaceae family such as Klebsiella pneumoniae produce additional siderophores such as yersiniabactin (Ybt) and contain the iroA locus encoding an Ent glycosylase that prevents Lcn2 binding.
Lcn2 Binding (binding) of
6) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.33 Pain Relevance 0.12
The data from this study suggest the following model in which Lcn2 monitors iron utilization by bacteria and activates the immune response when iron stores become depleted: At low bacterial density, secreted Ent binds Fe and Lcn2 in turn binds Fe-Ent to prevent delivery of iron to bacteria.
Lcn2 Binding (binds) of
7) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.22 Pain Relevance 0.19
Some pathogens avoid Lcn2 binding by attaching glucose to Ent (to make Gly-Ent) or by making alternative siderophores.
Lcn2 Binding (binding) of
8) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.15 Pain Relevance 0.07
In addition, Lcn2 bound to Ent stimulates release of the neutrophil-recruitment signal IL-8 from cultured respiratory cells.
Lcn2 Binding (bound) of in respiratory
9) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.20 Pain Relevance 0.10
The data from this study suggest the following model in which Lcn2 monitors iron utilization by bacteria and activates the immune response when iron stores become depleted: At low bacterial density, secreted Ent binds Fe and Lcn2 in turn binds Fe-Ent to prevent delivery of iron to bacteria.
Lcn2 Binding (binds) of
10) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.22 Pain Relevance 0.21
K. pneumoniae KPPR1 makes glycosylated Ent (Gly-Ent) and Ybt, neither of which Lcn2 is predicted to bind [11].
Lcn2 Binding (bind) of
11) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.35 Pain Relevance 0.05
Lcn2 binds bacillibactin of Bacillus anthracis, but B. anthracis also produces the unusual siderophore petrobactin that Lcn2 cannot bind [32].
Lcn2 Neg (cannot) Binding (bind) of associated with bacillus anthracis infection
12) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.34 Pain Relevance 0.04
To study each potential effect of Lcn2 on colonization, we exploited K. pneumoniae mutants that are predicted to be susceptible to Lcn2-mediated iron sequestration (iroA ybtS mutant) or inflammation (iroA mutant), or to not interact with Lcn2 (entB mutant).
Lcn2 Neg (not) Binding (interact) of associated with inflammation
13) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.41 Pain Relevance 0.16
As well as being an important human pathogen, K. pneumoniae is a tractable model organism that colonizes the nasopharynx and can be genetically manipulated to produce siderophore mutants that do or do not interact with Lcn2.
Lcn2 Neg (not) Binding (interact) of in nasopharynx
14) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.30 Pain Relevance 0.07
Lcn2 specifically binds Ent with an affinity similar to the Escherichia coli Ent receptor [2] and competes with bacteria for Ent binding.
Lcn2 Binding (binds) of
15) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.26 Pain Relevance 0
In lymphocytic cells, 24p3R is able to internalize Lcn2 alone or Lcn2 bound to a siderophore.
Lcn2 Binding (bound) of
16) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.45 Pain Relevance 0.06
Lcn2 specifically binds Ent with an affinity similar to the Escherichia coli Ent receptor [2] and competes with bacteria for Ent binding.
Lcn2 Binding (binding) of
17) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.35 Pain Relevance 0
If Fe is not depleted during colonization, then Lcn2 may bind primarily Fe-Ent.
Lcn2 Binding (bind) of
18) Confidence 0.31 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.31 Pain Relevance 0.14

General Comments

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