INT283402

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Context Info
Confidence 0.30
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 2.53
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nt5e) cytoplasm (Nt5e)
Nt5e (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 60 97.44 Very High Very High Very High
chemokine 72 89.24 High High
Inflammation 150 85.52 High High
Inflammatory response 54 57.48 Quite High
Antinociceptive 44 50.00 Quite Low
Pain 4 11.00 Low Low
anesthesia 18 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
intrathecal 8 5.00 Very Low Very Low Very Low
IPN 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 72 94.96 High High
Iron Overload 9 92.32 High High
Pneumonia 99 90.44 High High
Sepsis 27 89.12 High High
Lower Respiratory Tract Infection 9 86.08 High High
INFLAMMATION 204 85.52 High High
Sprains And Strains 144 84.48 Quite High
Bacterial Meningitis 9 51.36 Quite High
Bacteremia 18 36.76 Quite Low
Hemophilus Infection 9 28.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L final) were carried out with recombinant mNT5E at 37°C for 3 minutes in 100 mM HEPES, pH 7.0, 4 mM MgCl2 with adenosine 5'-monophosphate disodium salt (Fluka, 01930) as substrate.
mNT5E Binding (recombinant) of associated with adenocard
1) Confidence 0.30 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0.05
Cleaved mNT5E and thrombin were eluted in PBS while the GST tag remained bound to the column.
mNT5E Binding (bound) of
2) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0
Lcn2 specifically binds Ent with an affinity similar to the Escherichia coli Ent receptor [2] and competes with bacteria for Ent binding.
Ent Binding (binding) of
3) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.35 Pain Relevance 0
The data from this study suggest the following model in which Lcn2 monitors iron utilization by bacteria and activates the immune response when iron stores become depleted: At low bacterial density, secreted Ent binds Fe and Lcn2 in turn binds Fe-Ent to prevent delivery of iron to bacteria.
Ent Binding (binds) of
4) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.22 Pain Relevance 0.21
The data from this study suggest the following model in which Lcn2 monitors iron utilization by bacteria and activates the immune response when iron stores become depleted: At low bacterial density, secreted Ent binds Fe and Lcn2 in turn binds Fe-Ent to prevent delivery of iron to bacteria.
Ent Binding (binds) of
5) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.22 Pain Relevance 0.18
Since the iroA single mutant was not inhibited, production of Ybt circumvents the iron sequestration effect of Lcn2 binding to Ent.
Ent Binding (binding) of
6) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.39 Pain Relevance 0.16
To acquire iron within the host, bacteria secrete siderophores such as enterobactin (Ent) that bind ferric iron with greater affinity than mammalian proteins.
Ent Binding (bind) of
7) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0 Pain Relevance 0
Lcn2 is able to bind both ferric and aferric Ent, thereby depleting Ent from the microenvironment and inhibiting bacterial uptake of Ent-bound iron.
Ent-bound Binding (uptake) of
8) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.46 Pain Relevance 0
The data from this study suggest the following model in which Lcn2 monitors iron utilization by bacteria and activates the immune response when iron stores become depleted: At low bacterial density, secreted Ent binds Fe and Lcn2 in turn binds Fe-Ent to prevent delivery of iron to bacteria.
Ent Binding (binds) of
9) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.22 Pain Relevance 0.21
Lcn2 specifically binds Ent with an affinity similar to the Escherichia coli Ent receptor [2] and competes with bacteria for Ent binding.
Ent Binding (binds) of
10) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.26 Pain Relevance 0
To generate K. pneumoniae producing unmodified Ent that can be bound by Lcn2, the iroA locus was disrupted in the wild type and the ybtS mutant.
Ent Binding (bound) of
11) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.40 Pain Relevance 0.04

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