INT283406

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.98
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcn2) transport (Lcn2) extracellular space (Lcn2)
extracellular region (Lcn2)
Anatomy Link Frequency
respiratory 2
Lcn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 92.24 High High
chemokine 24 80.28 Quite High
Inflammatory response 18 17.12 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 66 92.24 High High
Infection 24 90.64 High High
Bacterial Infection 3 82.76 Quite High
Salmonella Infection 6 74.64 Quite High
Sprains And Strains 48 68.64 Quite High
Disease 6 66.64 Quite High
Pyogenic Liver Abscess 3 65.92 Quite High
Bacterial Respiratory Disease 6 58.76 Quite High
Hemophilus Infection 3 35.48 Quite Low
Bacterial Pneumonia 3 24.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a countermeasure, pathogens of the Enterobacteriaceae family such as Klebsiella pneumoniae produce additional siderophores such as yersiniabactin (Ybt) and contain the iroA locus encoding an Ent glycosylase that prevents Lcn2 binding.
Negative_regulation (prevents) of Lcn2 Binding (binding) of
1) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.33 Pain Relevance 0.12
This cluster encodes the Ent glycosylase IroB that prevents Lcn2 binding, and IroC to export, IroN to import, and IroD to linearize glycosylated Ent [18],[19].
Negative_regulation (prevents) of Lcn2 Binding (binding) of
2) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.45 Pain Relevance 0.11
Consistent with the observation that expression of the iroA locus prevents Lcn2 binding, Lcn2 does not stimulate IL-8 release from cultured respiratory cells in response to Gly-Ent.


Negative_regulation (prevents) of Lcn2 Binding (binding) of in respiratory
3) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.20 Pain Relevance 0.08

General Comments

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