INT283426

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 5.80
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcn2) transport (Lcn2) extracellular space (Lcn2)
extracellular region (Lcn2) plasma membrane (Nt5e) cytoplasm (Nt5e)
Anatomy Link Frequency
upper respiratory tract 2
respiratory 2
Lcn2 (Mus musculus)
Nt5e (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 144 95.80 Very High Very High Very High
Inflammation 288 92.08 High High
Inflammatory response 108 64.24 Quite High
anesthesia 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Infection 18 98.28 Very High Very High Very High
Pneumonia 198 97.56 Very High Very High Very High
Infection 144 94.96 High High
INFLAMMATION 396 92.08 High High
Iron Overload 18 84.80 Quite High
Sepsis 54 81.60 Quite High
Bacteremia 36 80.96 Quite High
Sprains And Strains 288 79.52 Quite High
Hemophilus Infection 18 51.00 Quite High
Salmonella Infection 36 47.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, Lcn2 bound to Ent induces release of IL-8 from cultured respiratory cells.
Lcn2 Binding (bound) of Ent in respiratory
1) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.26 Pain Relevance 0.10
When bacteria colonize the upper respiratory tract, the mucosa secretes the protein lipocalin 2 (Lcn2) that binds to the siderophore enterobactin (Ent) and disrupts bacterial iron acquisition.
Lcn2 Binding (binds) of Ent in upper respiratory tract
2) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.21 Pain Relevance 0.11
When bacteria colonize the upper respiratory tract, the mucosa secretes the protein lipocalin 2 (Lcn2) that binds to the siderophore enterobactin (Ent) and disrupts bacterial iron acquisition.
lipocalin 2 Binding (binds) of Ent in upper respiratory tract
3) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.21 Pain Relevance 0.11
Lcn2 specifically binds Ent with an affinity similar to the Escherichia coli Ent receptor [2] and competes with bacteria for Ent binding.
Lcn2 Binding (binds) of Ent
4) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.26 Pain Relevance 0
Lcn2 is able to bind both ferric and aferric Ent, thereby depleting Ent from the microenvironment and inhibiting bacterial uptake of Ent-bound iron.
Lcn2 Binding (bind) of Ent
5) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.37 Pain Relevance 0
However, whether Ybt can compensate for the loss of Ent bound by Lcn2 is unknown.
Lcn2 Binding (bound) of Ent
6) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.40 Pain Relevance 0.04
Lcn2 specifically binds Ent with an affinity similar to the Escherichia coli Ent receptor [2] and competes with bacteria for Ent binding.
Lcn2 Binding (binding) of Ent
7) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.35 Pain Relevance 0
Since the iroA single mutant was not inhibited, production of Ybt circumvents the iron sequestration effect of Lcn2 binding to Ent.
Lcn2 Binding (binding) of Ent
8) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.39 Pain Relevance 0.16
In addition, Lcn2 bound to Ent stimulates release of the neutrophil-recruitment signal IL-8 from cultured respiratory cells.
Lcn2 Binding (bound) of Ent in respiratory
9) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.20 Pain Relevance 0.10
Perhaps due to the actions of Lcn2, successful pathogens do not typically depend solely on Ent for iron [9].
Lcn2 Neg (not) Binding (depend) of Ent
10) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.21 Pain Relevance 0.13
Constructing mutants in the iroA locus will allow study of the effects of Lcn2 binding to non-glycosylated Ent (Ent).
Lcn2 Binding (binding) of Ent
11) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.40 Pain Relevance 0.05
To generate K. pneumoniae producing unmodified Ent that can be bound by Lcn2, the iroA locus was disrupted in the wild type and the ybtS mutant.
Lcn2 Binding (bound) of Ent
12) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.40 Pain Relevance 0.04
The iroA mutant is predicted to produce Ent that interacts with Lcn2, is not predicted to be susceptible to iron sequestration since it makes Ybt, and colonizes similarly to the wild type (Figure 7).
Lcn2 Binding (interacts) of Ent
13) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.22 Pain Relevance 0.09
Constructing mutants in the iroA locus will allow study of the effects of Lcn2 binding to non-glycosylated Ent (Ent).
Lcn2 Binding (binding) of Ent
14) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.40 Pain Relevance 0.05
Constructing mutants in the iroA locus will allow study of the effects of Lcn2 binding to non-glycosylated Ent (Ent).
Lcn2 Binding (binding) of Ent
15) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.40 Pain Relevance 0.05
Constructing mutants in the iroA locus will allow study of the effects of Lcn2 binding to non-glycosylated Ent (Ent).
Lcn2 Binding (binding) of Ent
16) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.40 Pain Relevance 0.05
To generate K. pneumoniae producing unmodified Ent that can be bound by Lcn2, the iroA locus was disrupted in the wild type and the ybtS mutant.
Lcn2 Binding (bound) of Ent
17) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.40 Pain Relevance 0.04
If Fe is not depleted during colonization, then Lcn2 may bind primarily Fe-Ent.
Lcn2 Binding (bind) of Ent
18) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.31 Pain Relevance 0.14

General Comments

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