INT283434

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.33
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lcn2, IL8) extracellular region (Lcn2, IL8) cytosol (Lcn2)
signal transduction (IL8) transport (Lcn2) intracellular (IL8)
Anatomy Link Frequency
respiratory 6
Lcn2 (Mus musculus)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 48 94.32 High High
Inflammation 96 84.28 Quite High
Inflammatory response 36 30.40 Quite Low
anesthesia 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Respiratory Disease 12 98.76 Very High Very High Very High
INFLAMMATION 132 84.28 Quite High
Sprains And Strains 96 76.04 Quite High
Infection 48 75.12 Quite High
Pneumonia 66 5.00 Very Low Very Low Very Low
Suicidal Behaviour 18 5.00 Very Low Very Low Very Low
Sepsis 18 5.00 Very Low Very Low Very Low
Salmonella Infection 12 5.00 Very Low Very Low Very Low
Bacteremia 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lipocalin 2 induces IL-8 release from cultured respiratory cells in response to unmodified but not glycosylated enterobactin
Lipocalin 2 Positive_regulation (induces) of Localization (release) of IL-8 in respiratory
1) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.26 Pain Relevance 0.07
Consistent with the observation that expression of the iroA locus prevents Lcn2 binding, Lcn2 does not stimulate IL-8 release from cultured respiratory cells in response to Gly-Ent.


Lcn2 Neg (not) Positive_regulation (stimulate) of Localization (release) of IL-8 in respiratory
2) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.20 Pain Relevance 0.07
Whereas co-incubation of Ent with Lcn2 induced IL-8 release greater than 20-fold, co-incubation of Gly-Ent and Lcn2 did not stimulate IL-8 release above the level induced by Lcn2 alone (Figure 8).
Lcn2 Positive_regulation (induced) of Localization (release) of IL-8
3) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.21 Pain Relevance 0.09
Whereas co-incubation of Ent with Lcn2 induced IL-8 release greater than 20-fold, co-incubation of Gly-Ent and Lcn2 did not stimulate IL-8 release above the level induced by Lcn2 alone (Figure 8).
Lcn2 Positive_regulation (induced) of Localization (release) of IL-8
4) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.26 Pain Relevance 0.09
Whereas co-incubation of Ent with Lcn2 induced IL-8 release greater than 20-fold, co-incubation of Gly-Ent and Lcn2 did not stimulate IL-8 release above the level induced by Lcn2 alone (Figure 8).
Lcn2 Positive_regulation (induced) of Localization (release) of IL-8
5) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.20 Pain Relevance 0.09
In addition, Lcn2 bound to Ent stimulates release of the neutrophil-recruitment signal IL-8 from cultured respiratory cells.
Lcn2 Positive_regulation (stimulates) of Localization (release) of IL-8 in respiratory
6) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.20 Pain Relevance 0.10

General Comments

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