INT283460

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.14
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DLAT) small molecule metabolic process (DLAT) Golgi apparatus (CTLA4)
plasma membrane (CTLA4) transferase activity, transferring acyl groups (DLAT)
Anatomy Link Frequency
immune system 1
CTLA4 (Homo sapiens)
DLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 201 65.36 Quite High
Inflammation 69 5.00 Very Low Very Low Very Low
fibrosis 42 5.00 Very Low Very Low Very Low
pruritus 42 5.00 Very Low Very Low Very Low
tolerance 42 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
halothane 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 738 100.00 Very High Very High Very High
Autoimmune Disease 90 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 12 100.00 Very High Very High Very High
Diabetes Mellitus 3 100.00 Very High Very High Very High
Necrosis 9 97.68 Very High Very High Very High
Cancer 12 97.32 Very High Very High Very High
Gallstones 69 57.84 Quite High
Disease 117 39.56 Quite Low
Disease Progression 24 12.40 Low Low
Apoptosis 81 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although an association of CTLA-4 variants and susceptibility to PBC could not be demonstrated in all studies [110, 111], Poupon et al. [112] most recently confirmed a potential role of TNF?
CTLA-4 Binding (association) of PBC associated with biliary liver cirrhosis
1) Confidence 0.06 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.02 Pain Relevance 0.03
Although an association of CTLA-4 variants and susceptibility to PBC could not be demonstrated in all studies [110, 111], Poupon et al. [112] most recently confirmed a potential role of TNF?
CTLA-4 Binding (association) of PBC associated with biliary liver cirrhosis
2) Confidence 0.06 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.02 Pain Relevance 0.03
and of cytotoxic T lymphocyte antigen 4 (CTLA-4), a key regulator of the adaptive immune system, have been repeatedly associated with susceptibility to different autoimmune diseases (such as type I diabetes mellitus and systemic lupus erythematosus) and were also associated with PBC [104–109].
CTLA-4 Binding (associated) of PBC in immune system associated with biliary liver cirrhosis, autoimmune disease, diabetes mellitus and systemic lupus erythematosus
3) Confidence 0.06 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.10 Pain Relevance 0.03

General Comments

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