INT283464

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Context Info
Confidence 0.07
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DLAT) signal transduction (CD4) small molecule metabolic process (DLAT)
cell adhesion (CD4) plasma membrane (CD4) transferase activity, transferring acyl groups (DLAT)
Anatomy Link Frequency
B cells 1
CD4 (Homo sapiens)
DLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 67 72.96 Quite High
tolerance 14 46.32 Quite Low
Inflammation 23 42.52 Quite Low
fibrosis 14 5.00 Very Low Very Low Very Low
pruritus 14 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 246 100.00 Very High Very High Very High
Injury 9 72.16 Quite High
Autoimmune Disease 30 60.60 Quite High
INFLAMMATION 23 42.52 Quite Low
Primary Sclerosing Cholangitis 5 36.12 Quite Low
Hepatitis Virus Infection 2 35.84 Quite Low
Stress 3 30.60 Quite Low
Apoptosis 27 30.32 Quite Low
Disease 39 5.00 Very Low Very Low Very Low
Gallstones 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The autoreactive CD4 and CD8 T cells infiltrating the liver in PBC recognize the same PDC-E2 domain (peptides 159–167 and 163–176) [189, 190], and the same accounts for the dominant autoreactive B cells [191].
CD4 Binding (recognize) of PDC-E2 in B cells associated with biliary liver cirrhosis
1) Confidence 0.07 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.69 Pain Relevance 0.04

General Comments

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