INT283501

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Context Info
Confidence 0.19
First Reported 2009
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.66
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC4A2) transmembrane transport (SLC4A2)
Anatomy Link Frequency
hepatocyte 2
SLC4A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 16 99.00 Very High Very High Very High
Bile 268 94.92 High High
Kinase C 4 71.08 Quite High
Inflammation 92 36.08 Quite Low
fibrosis 56 27.64 Quite Low
pruritus 56 5.00 Very Low Very Low Very Low
tolerance 56 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 984 99.28 Very High Very High Very High
Increased Venous Pressure Under Development 8 91.76 High High
Gallstones 92 88.24 High High
Disease 156 65.52 Quite High
Injury 36 39.84 Quite Low
INFLAMMATION 92 36.08 Quite Low
Fibrosis 64 27.64 Quite Low
Apoptosis 108 24.76 Low Low
Osteoporosis 44 12.32 Low Low
Death 20 12.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is yet unclear whether increased expression of AE2 isoforms contributes to the beneficial effect of combined treatment with UDCA and corticosteroids in PBC.
Spec (whether) Positive_regulation (increased) of Gene_expression (expression) of AE2 associated with biliary liver cirrhosis and corticosteroid
1) Confidence 0.19 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.40 Pain Relevance 0.12
UDCA stimulates both AE2 expression [242] and bicarbonate secretion [241].
Positive_regulation (stimulates) of Gene_expression (expression) of AE2
2) Confidence 0.13 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.40 Pain Relevance 0.37
It is yet unclear whether increased expression of AE2 isoforms contributes to the beneficial effect of combined treatment with UDCA and corticosteroids in PBC.
Spec (whether) Positive_regulation (contributes) of Gene_expression (expression) of AE2 associated with biliary liver cirrhosis and corticosteroid
3) Confidence 0.13 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.40 Pain Relevance 0.12
Experimentally, enhanced expression of alternative AE2 isoforms and enhanced transport capacity for bicarbonate in human cholangiocytes and in a hepatocyte cell line were demonstrated [283].
Positive_regulation (enhanced) of Gene_expression (expression) of AE2 in hepatocyte
4) Confidence 0.11 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.46 Pain Relevance 0.12

General Comments

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