INT283506

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.00
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC4A2) transmembrane transport (SLC4A2)
Anatomy Link Frequency
hepatocyte 1
SLC4A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 402 98.96 Very High Very High Very High
corticosteroid 24 98.64 Very High Very High Very High
Kinase C 6 75.12 Quite High
Inflammation 138 36.08 Quite Low
fibrosis 84 31.68 Quite Low
Chronic pancreatitis 1 25.12 Quite Low
abdominal pain 4 23.08 Low Low
pruritus 85 5.00 Very Low Very Low Very Low
tolerance 84 5.00 Very Low Very Low Very Low
agonist 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 1476 99.96 Very High Very High Very High
Cancer 35 99.76 Very High Very High Very High
Squamous Cell Carcinoma 7 96.72 Very High Very High Very High
Increased Venous Pressure Under Development 12 95.80 Very High Very High Very High
Adenocarcinoma 9 95.60 Very High Very High Very High
Metastasis 4 95.08 Very High Very High Very High
Gallstones 138 88.24 High High
Rhinitis 7 84.84 Quite High
Malignant Neoplastic Disease 11 67.08 Quite High
Disease 234 65.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunochistochemical study showed that the tumor cells were positive for cytokeratin AE1 and AE2.
Gene_expression (positive) of AE2 associated with cancer
1) Confidence 0.47 Published 2010 Journal Cases J Section Body Doc Link PMC2825199 Disease Relevance 1.47 Pain Relevance 0
AE2 expression and biliary bicarbonate secretion is usually diminished in PBC [241].
Gene_expression (expression) of AE2 associated with biliary liver cirrhosis
2) Confidence 0.22 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.46 Pain Relevance 0.15
It is yet unclear whether increased expression of AE2 isoforms contributes to the beneficial effect of combined treatment with UDCA and corticosteroids in PBC.
Gene_expression (expression) of AE2 associated with biliary liver cirrhosis and corticosteroid
3) Confidence 0.22 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.40 Pain Relevance 0.12
UDCA stimulates both AE2 expression [242] and bicarbonate secretion [241].
Gene_expression (expression) of AE2
4) Confidence 0.22 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.40 Pain Relevance 0.37
Experimentally, enhanced expression of alternative AE2 isoforms and enhanced transport capacity for bicarbonate in human cholangiocytes and in a hepatocyte cell line were demonstrated [283].
Gene_expression (expression) of AE2 in hepatocyte
5) Confidence 0.19 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.46 Pain Relevance 0.12
In PBC, expression of the hepatic AE2 and biliary bicarbonate secretion by AE2 are impaired [240, 241].
Gene_expression (expression) of AE2 associated with biliary liver cirrhosis
6) Confidence 0.16 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.41 Pain Relevance 0.32
In PBC, expression of the hepatic AE2 and biliary bicarbonate secretion by AE2 are impaired [240, 241].
Gene_expression (expression) of AE2 associated with biliary liver cirrhosis
7) Confidence 0.15 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.41 Pain Relevance 0.32

General Comments

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