INT283507

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.20
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DLAT) small molecule metabolic process (DLAT) transferase activity, transferring acyl groups (DLAT)
DLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 134 99.16 Very High Very High Very High
tolerance 28 83.00 Quite High
fibrosis 28 80.24 Quite High
Inflammatory response 4 79.44 Quite High
Kinase C 2 75.32 Quite High
Inflammation 46 74.88 Quite High
pruritus 28 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 492 100.00 Very High Very High Very High
Cholangitis 6 99.70 Very High Very High Very High
Targeted Disruption 6 99.48 Very High Very High Very High
Sprains And Strains 4 98.52 Very High Very High Very High
Increased Venous Pressure Under Development 4 96.00 Very High Very High Very High
Autoimmune Disease 60 89.76 High High
Gallstones 46 84.40 Quite High
Fibrosis 32 80.24 Quite High
INFLAMMATION 46 79.44 Quite High
Necrosis 6 68.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In PBC, expression of the hepatic AE2 and biliary bicarbonate secretion by AE2 are impaired [240, 241].
Negative_regulation (impaired) of Gene_expression (expression) of PBC associated with biliary liver cirrhosis
1) Confidence 0.28 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 0.41 Pain Relevance 0.32
In two genetically manipulated mouse strains, spontaneous occurrence of a PBC-like lymphoid cholangitis together with positivity for anti-PDC-E2 within several weeks of life was reported when either transgenic expression of a dominant negative TGF-?
Negative_regulation (reported) of Gene_expression (positivity) of anti-PDC-E2 associated with targeted disruption, cholangitis, biliary liver cirrhosis and sprains and strains
2) Confidence 0.28 Published 2009 Journal Semin Immunopathol Section Body Doc Link PMC2758170 Disease Relevance 1.79 Pain Relevance 0.16

General Comments

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