INT283536

Context Info Confidence 0.36 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 3.69 Pain Relevance 0

nucleoplasm (Setx) nucleus (Setx) helicase activity (Setx) molecular_function (Setx) cytoplasm (Setx)

Anatomy Link Frequency lateral 2 Setx (Mus musculus)

Pain Link Frequency Relevance Heat Action potential 16 5.00 carpal tunnel syndrome 4 5.00 cytokine 2 5.00 Glutamate receptor 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Neuropathic Pain 16 100.00 Paraplegia 4 100.00 Motor Neuron Diseases 4 100.00 Frailty 26 98.68 Spastic Paraparesis 4 97.88 Syndrome 10 96.16 Ataxia 4 93.04 Neurodegenerative Disease 2 89.60 Lipodystrophy 2 86.68 Hereditary Spastic Paraplegia 2 80.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The senataxin gene (SETX), primary associated with autosomal dominant juvenile amyotrophic lateral sclerosis (ALS4) and spastic paraplegia without neuropathy (SPG19), has now also been associated with distal HMN with pyramidal features [3, 8].

senataxin Binding (associated) of in lateral associated with paraplegia, neuropathic pain and motor neuron diseases

1) Confidence 0.36 Published 2009 Journal Neurogenetics Section Body Doc Link PMC2758216 Disease Relevance 1.85 Pain Relevance 0

The senataxin gene (SETX), primary associated with autosomal dominant juvenile amyotrophic lateral sclerosis (ALS4) and spastic paraplegia without neuropathy (SPG19), has now also been associated with distal HMN with pyramidal features [3, 8].

SETX Binding (associated) of in lateral associated with paraplegia, neuropathic pain and motor neuron diseases

2) Confidence 0.36 Published 2009 Journal Neurogenetics Section Body Doc Link PMC2758216 Disease Relevance 1.84 Pain Relevance 0

General Comments

This test has worked.