INT283560

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.84
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) plasma membrane (Ptk2)
cytoskeleton (Ptk2) nucleus (Ptk2) extracellular matrix organization (Ptk2)
Anatomy Link Frequency
brains 2
fibroblast 2
Ptk2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 42 98.84 Very High Very High Very High
imagery 11 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Mechanosensation 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 174 99.58 Very High Very High Very High
Adhesions 163 99.36 Very High Very High Very High
Cancer 270 98.92 Very High Very High Very High
Adenocarcinoma 3 98.60 Very High Very High Very High
Apoptosis 117 97.52 Very High Very High Very High
Neointima 9 96.68 Very High Very High Very High
Polycystic Kidney Disease 62 93.36 High High
Coronary Artery Disease 2 85.08 High High
Hyperplasia 8 82.12 Quite High
Glioblastoma 41 58.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of FAK expression led to inhibition of MMP-9 gene expression [23], whereas MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts [24].
Negative_regulation (Inhibition) of Gene_expression (expression) of FAK in fibroblast associated with adhesions
1) Confidence 0.40 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.48 Pain Relevance 0
In contrast, inhibiting FAK expression and signaling reduced motility of adenocarcinoma cells [23].
Negative_regulation (inhibiting) of Gene_expression (expression) of FAK associated with adenocarcinoma
2) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.68 Pain Relevance 0
Also, FACS analysis of single and co-cultures of glioma cells revealed that FAK expression was significantly inhibited by hUCBSC treatment (Figure 3B).
Negative_regulation (inhibited) of Gene_expression (expression) of FAK associated with glioma
3) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.65 Pain Relevance 0
These results confirm that FAK and VEGF expression were highly downregulated in vivo in hUCBSC-treated tumor brains.
Negative_regulation (downregulated) of Gene_expression (expression) of FAK in brains associated with cancer
4) Confidence 0.40 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.97 Pain Relevance 0
Analysis of adherent HT29 cells confirmed that loss of FAK activation preceded decay in Mcl-1 protein levels (Figure 4F) observed in cells in suspension (Figure 4D).
Negative_regulation (loss) of Gene_expression (decay) of FAK
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.39 Pain Relevance 0.04
Interestingly, decreased FAK activation and protein levels preceded the alterations in Mcl-1 and Bim levels (Figure 4D).
Negative_regulation (decreased) of Gene_expression (activation) of FAK
6) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.31 Pain Relevance 0.05
Downregulation of FAK, talin1, talin 2, profilin, tensin and Arp2 was noticed in treated 5310 cells whereas in 4910 cells, FAK, talin1, talin2, vinculin, actinin, tensin and Arp2 levels were reduced with both MU-sh and MC-sh treatments (Fig. 8A).
Negative_regulation (reduced) of Gene_expression (levels) of FAK
7) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.43 Pain Relevance 0
InADPKD cells, expression of FAK is lost from the focal adhesion complex.
Negative_regulation (lost) of Gene_expression (expression) of FAK associated with adhesions
8) Confidence 0.12 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.92 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox