INT283561

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 1.10
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) plasma membrane (Ptk2)
cytoskeleton (Ptk2) nucleus (Ptk2) extracellular matrix organization (Ptk2)
Anatomy Link Frequency
smooth muscle cells 6
vessels 2
Ptk2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 21 98.44 Very High Very High Very High
Inflammation 10 94.60 High High
cytokine 5 68.40 Quite High
fibrosis 10 5.00 Very Low Very Low Very Low
Analgesic 5 5.00 Very Low Very Low Very Low
Versed 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 101 99.68 Very High Very High Very High
Stress 18 98.34 Very High Very High Very High
Apoptosis 46 97.12 Very High Very High Very High
INFLAMMATION 10 94.60 High High
Neointima 45 81.96 Quite High
Pathologic Constriction 5 55.00 Quite High
Hyperplasia 11 54.24 Quite High
Colon Cancer 25 50.00 Quite Low
Left Ventricular Hypertrophy 10 50.00 Quite Low
Vasculitis 15 48.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested the possible role of the components of the basement membrane in regulating the expression of FAK and FAK (pY397) in smooth muscle cells.
Spec (possible) Regulation (regulating) of Gene_expression (expression) of FAK in smooth muscle cells
1) Confidence 0.42 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
Firstly, shear stress and high intraluminal pressure were reported to activate integrins and FAK and up-regulate expression of FAK [34–36].
Regulation (regulate) of Gene_expression (expression) of FAK associated with stress
2) Confidence 0.42 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.51 Pain Relevance 0.12
We tested the possible role of the components of the basement membrane in regulating the expression of FAK and FAK (pY397) in smooth muscle cells.
Spec (possible) Regulation (regulating) of Gene_expression (expression) of FAK in smooth muscle cells
3) Confidence 0.42 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
As shown in Figure 3C, no change was detected in the myocardial levels of FAK (Focal Adhesion Kinase), JNK (c-Jun N-Terminal Kinase) or Shp2 (Src homology region 2, phosphatase 2) after treatment with siMEF2C.
Regulation (detected) of Gene_expression (levels) of FAK associated with adhesions
4) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.10 Pain Relevance 0
The immunostaining of FAK and FAK(pY397) in serial sections revealed that increased expression of FAK was accompanied by an increase of expression of FAK(pY397) Fig. 1d–e).Fig. 1Confocal micrographs of FAK and FAK(pY397) immunostaining in normal (NV), control (only ligation) (CLV), and AV-shunt (AV-S) collateral vessels. a–d: FAK; e: FAK(pY397). a: NV; b: CLV, c, d and e: AV-S.
Regulation (control) of Gene_expression (expression) of FAK in vessels
5) Confidence 0.25 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
Here, cells do not proliferate and express only very low levels of integrins and FAK and FAK(pY397) indicating that extracellular matrix components can differentially regulate expression of integrins, FAK and FAK(pY397) as well as smooth muscle cell proliferation.
Regulation (regulate) of Gene_expression (expression) of FAK in smooth muscle cell
6) Confidence 0.25 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.13 Pain Relevance 0
Interestingly, decreased FAK activation and protein levels preceded the alterations in Mcl-1 and Bim levels (Figure 4D).
Regulation (alterations) of Gene_expression (activation) of FAK
7) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.36 Pain Relevance 0.05

General Comments

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