INT283566

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) plasma membrane (Ptk2)
cytoskeleton (Ptk2) nucleus (Ptk2) extracellular matrix organization (Ptk2)
Anatomy Link Frequency
smooth muscle cells 2
epithelial cells 1
Ptk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Analgesic 4 5.00 Very Low Very Low Very Low
Mechanosensation 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Versed 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Mechanotransduction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 71 100.00 Very High Very High Very High
Polycystic Kidney Disease 62 91.24 High High
Coronary Artery Disease 2 89.52 High High
Cyst 32 35.76 Quite Low
Congenital Anomalies 6 14.56 Low Low
Neointima 36 5.00 Very Low Very Low Very Low
Disease 30 5.00 Very Low Very Low Very Low
Apoptosis 17 5.00 Very Low Very Low Very Low
Vasculitis 12 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Note that AV-S showed strong staining for both FAK and FAK(pY397). d and e showing colocalization of FAK and FAK(pY397) in serial sections
Localization (colocalization) of FAK
1) Confidence 0.75 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
Note that AV-S showed strong staining for both FAK and FAK(pY397). d and e showing colocalization of FAK and FAK(pY397) in serial sections
Localization (colocalization) of FAK
2) Confidence 0.75 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
We found that smooth muscle cells cultured on fibronectin substrate highly expressed FAK and FAK (pY397), to a lesser amount on Laminin substrate and very little inside a Matrigel basement membrane matrix (Fig. 2a–f, Table 3).Fig. 2Confocal micrographs of FAK and FAK(pY397) immunostaining in smooth muscle cells cultured on different substances.
Localization (micrographs) of FAK in smooth muscle cells
3) Confidence 0.70 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
We found that smooth muscle cells cultured on fibronectin substrate highly expressed FAK and FAK (pY397), to a lesser amount on Laminin substrate and very little inside a Matrigel basement membrane matrix (Fig. 2a–f, Table 3).Fig. 2Confocal micrographs of FAK and FAK(pY397) immunostaining in smooth muscle cells cultured on different substances.
Localization (micrographs) of FAK in smooth muscle cells
4) Confidence 0.70 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0 Pain Relevance 0
In normal epithelial cells, PC-1 is found in a complex with talin (TAL), paxillin (PAX), vinculin (VINC), focal adhesion kinase (FAK), c-src (SRC), p130-cas (CAS), nephrocystin (NPH1) and tensin (TEN).
Localization (focal) of adhesion kinase in epithelial cells associated with adhesions
5) Confidence 0.18 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.93 Pain Relevance 0

General Comments

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