INT283569

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.25
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
extracellular matrix 3
connective tissues 1
smooth muscle cell 1
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 42 100.00 Very High Very High Very High
ischemia 35 79.84 Quite High
Inflammatory mediators 7 60.60 Quite High
Inflammation 35 21.56 Low Low
Potency 4 13.52 Low Low
cytokine 35 5.00 Very Low Very Low Very Low
chemokine 20 5.00 Very Low Very Low Very Low
Inflammatory response 17 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 244 99.68 Very High Very High Very High
Metastasis 72 97.12 Very High Very High Very High
Neointima 18 97.12 Very High Very High Very High
Stroke 81 92.20 High High
Neutropenia 1 87.04 High High
Cv Unclassified Under Development 20 79.84 Quite High
Adhesions 42 72.40 Quite High
INFLAMMATION 64 60.20 Quite High
Brain Injury 5 56.12 Quite High
Wound Healing 4 53.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, MMP-2 and -9 degrade EMC macromolecules in the basement membranes and other interstitial connective tissues [13].
Protein_catabolism (degrade) of MMP-2 in connective tissues
1) Confidence 0.77 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 1.16 Pain Relevance 0
The fact that MMP-2 and -9 degrade type IV collagen, laminin and fibronectin, which are major components of the basal lamina around cerebral blood vessels and the extracellular matrix, will certainly underpin this theory [10,38,101,106].
Protein_catabolism (degrade) of MMP-2 in basal lamina
2) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.72 Pain Relevance 0.20
MMP-2, MMP-9, and uPA are known to be involved in the degradation of extracellular matrix and play a critical role in tumor invasion and metastasis.
Protein_catabolism (degradation) of MMP-2 in extracellular matrix associated with cancer, metalloproteinase and metastasis
3) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 1.03 Pain Relevance 0.36
We demonstrated previously that active extracellular proteolysis is present in the process of arteriogenesis, which includes increased expression of MMP-2 and -9, degradation of the basement membrane and smooth muscle cell migration resulting in neointima formation [2].
Protein_catabolism (degradation) of MMP-2 in smooth muscle cell associated with neointima
4) Confidence 0.08 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.17 Pain Relevance 0
We demonstrated previously that active extracellular proteolysis is present in the process of arteriogenesis, which includes increased expression of MMP-2 and -9, degradation of the basement membrane and smooth muscle cell migration resulting in neointima formation [2].
Protein_catabolism (degradation) of MMP-2 in basement membrane associated with neointima
5) Confidence 0.03 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.17 Pain Relevance 0

General Comments

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