INT28358

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 3.52
Pain Relevance 7.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nanog) nucleoplasm (Nanog) nucleolus (Nanog)
nucleus (Nanog) embryo development (Nanog) DNA binding (Nanog)
Anatomy Link Frequency
neurons 2
median eminence 2
bar 1
cerebellar anlage 1
Neuro-2a 1
Nanog (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 74 100.00 Very High Very High Very High
Calcitonin gene-related peptide 22 100.00 Very High Very High Very High
projection neuron 3 100.00 Very High Very High Very High
substance P 55 99.48 Very High Very High Very High
Dopamine 6 99.12 Very High Very High Very High
Pyramidal cell 32 96.36 Very High Very High Very High
Neuropeptide 22 95.72 Very High Very High Very High
Substantia nigra 5 93.20 High High
Neurotransmitter 70 91.84 High High
Glutamate receptor 10 91.60 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 99.24 Very High Very High Very High
Targeted Disruption 71 98.24 Very High Very High Very High
Disease 98 97.80 Very High Very High Very High
Cancer 32 96.32 Very High Very High Very High
Aids-related Complex 4 96.12 Very High Very High Very High
Death 38 95.88 Very High Very High Very High
Teratoma 80 93.88 High High
Frailty 8 88.92 High High
Coronary Artery Disease 5 85.76 High High
Apoptosis 24 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the synthesis of NPY, ENK and NT is enhanced in TIDA neurons during lactation and that these neuromessengers may be co-released together with DA from the ME to regulate the suckling-induced prolactin secretion at the hypothalamic and/or pituitary levels.
Gene_expression (synthesis) of ENK in neurons associated with enkephalin
1) Confidence 0.70 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680430 Disease Relevance 0.09 Pain Relevance 0.63
NPY-, ENK- and NT-irs were intensely expressed and coexisted in virtually all TH-ir endings in the median eminence (ME) of nursing mice.
Gene_expression (expressed) of ENK in median eminence associated with enkephalin
2) Confidence 0.70 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680430 Disease Relevance 0.08 Pain Relevance 0.66
In the arcuate nucleus (ARC) of colchicine-treated nursing mice which received peripheral injections of Fluoro-Gold (FG) to retrogradely label neuroendocrine cells, virtually all dorsal A12 TH-ir perikarya simultaneously expressed, with individual variations, NPY-, ENK- and NT-irs, and all contained FG.
Gene_expression (expressed) of ENK in arcuate nucleus associated with aids-related complex and enkephalin
3) Confidence 0.70 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680430 Disease Relevance 0.10 Pain Relevance 0.65
We examined PPE and PPT (preprotachykinin) gene expression in striatal projection neurons and in striatal projection fibers immunoreactive for the PPE product enkephalin (ENK) and the PPT product substance P (SP) in a transgenic HD model, the R6/2 mouse, to see if changes occur in these neuron types similar to those seen in early adult-onset HD.
Spec (examined) Gene_expression (expression) of ENK in projection neurons associated with targeted disruption, enkephalin, projection neuron, disease and substance p
4) Confidence 0.65 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12586547 Disease Relevance 0.67 Pain Relevance 0.57
NPY-, ENK- and NT-irs were intensely expressed and coexisted in virtually all TH-ir endings in the median eminence (ME) of nursing mice.
Gene_expression (coexisted) of ENK in median eminence associated with enkephalin
5) Confidence 0.61 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680430 Disease Relevance 0.08 Pain Relevance 0.66
As was observed for CGRP, Leu-Enk expression was only detected in induced MSCs, specifically D12 cells (Fig. 1D, white bar).


Gene_expression (expression) of Enk in bar associated with calcitonin gene-related peptide
6) Confidence 0.58 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.06 Pain Relevance 0.62
VIP was synthesized by uninduced cells, while D12 cells produced CGRP and Leu-Enk, as well as SP.
Gene_expression (produced) of Enk associated with substance p and calcitonin gene-related peptide
7) Confidence 0.58 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.18 Pain Relevance 1.00
We have previously demonstrated that no expression of Nanog or Pou5f1 was detected following Nkx2-5(+) CPC derivation and extended culture in vitro.
Neg (no) Gene_expression (expression) of Nanog
8) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.37 Pain Relevance 0
In contrast, colonies of undifferentiated ESCs and high expression levels of Nanog and Pou5f1 were found in cultures of the sorted GFP(?)
Gene_expression (expression) of Nanog
9) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.34 Pain Relevance 0
Enk expression is tightly regulated by cortical inputs (Uhl et al., 1988) and decreased cortical communication will reduce enk expression in these MSSNs.
Gene_expression (expression) of Enk
10) Confidence 0.55 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.06 Pain Relevance 0.38
These neurons express enk (enkephalin) and DA (dopamine) D2 receptors.
Gene_expression (express) of enk in neurons associated with dopamine and enkephalin
11) Confidence 0.55 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.25 Pain Relevance 0.36
Enk expression is tightly regulated by cortical inputs (Uhl et al., 1988) and decreased cortical communication will reduce enk expression in these MSSNs.
Gene_expression (expression) of enk
12) Confidence 0.55 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.07 Pain Relevance 0.33
Decreased enk expression is one of the earliest molecular markers of neuropathology in HD mice (Menalled et al., 2000).
Gene_expression (expression) of enk
13) Confidence 0.55 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2850512 Disease Relevance 0.06 Pain Relevance 0.08
Mouse neuroblastoma Neuro-2a cells were examined for the expression of pro-enkephalin mRNA, protein, and Met-enkephalin ([Met]-Enk) peptide.
Spec (examined) Gene_expression (expression) of Enk in Neuro-2a associated with neuroblastoma and enkephalin
14) Confidence 0.54 Published 1995 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 8674823 Disease Relevance 0.17 Pain Relevance 0.52
No colonies of undifferentiated ESCs were detected as confirmed by the absence of Pou5f1 and Nanog expression.


Gene_expression (expression) of Nanog
15) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0 Pain Relevance 0.04
In contrast, colonies of undifferentiated ESCs and high expression levels of Nanog and Pou5f1 were found in cultures of the sorted GFP(?)
Gene_expression (levels) of Nanog
16) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902505 Disease Relevance 0.34 Pain Relevance 0
On PD 1, ENK axons are present in the intermediate layer of the cerebellar anlage.
Gene_expression (present) of ENK in cerebellar anlage associated with enkephalin
17) Confidence 0.44 Published 1989 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2752575 Disease Relevance 0 Pain Relevance 0.49
Further, a transient appearance of ENK in discrete populations of developing climbing fibers suggests several developmental events: (1) cell death in the inferior olive, (2) collateral regression, or (3) a transient expression of this peptide, that may be characteristic of this chemically defined system of axons.
Gene_expression (appearance) of ENK in climbing fibers associated with enkephalin and death
18) Confidence 0.38 Published 1989 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 2752575 Disease Relevance 0.10 Pain Relevance 0.70
Reverse transcription polymerase chain reaction (RT-PCR) was used to compare the expression of embryonic markers (Oct4, NANOG, Rex1), cardiac transcription factors (Nkx2.5, MEF2C), ventricular specific proteins (?
Gene_expression (expression) of NANOG
19) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0 Pain Relevance 0
In our microarray analysis, we observed high expression of pluripotency-related genes involved in the core hESC regulatory circuitry, including OCT4, SOX2, and NANOG, as well as CRYPTO 1 and 3, LCK, and HESX1.
Gene_expression (expression) of NANOG
20) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.18 Pain Relevance 0

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