INT283606

Context Info Confidence 0.44 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.13 Pain Relevance 0

cytoskeletal protein binding (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn) intracellular (Gphn) cytoplasm (Gphn)

Gphn (Mus musculus)

Pain Link Frequency Relevance Heat tetrodotoxin 2 9.08 antagonist 14 5.00 Spinal cord 4 5.00 Glutamate receptor 4 5.00 imagery 4 5.00 Neurotransmitter 2 5.00 Hippocampus 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 14 66.16 Sprains And Strains 6 5.00 Disease 2 5.00 Neurologic Manifestations 2 5.00 Death 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When the same experiments were performed using overexpression of the NLS-tagged intrabodies, a dramatic change in gephyrin distribution was observed (Fig. 2b).

Regulation (change) of gephyrin

1) Confidence 0.44 Published 2007 Journal J Mol Neurosci Section Body Doc Link PMC2758390 Disease Relevance 0 Pain Relevance 0

First, both intrabodies immunoprecipitate gephyrin upon their co-expression in HEK 293 cells.

Regulation (immunoprecipitate) of gephyrin

2) Confidence 0.32 Published 2007 Journal J Mol Neurosci Section Body Doc Link PMC2758390 Disease Relevance 0.13 Pain Relevance 0

General Comments

This test has worked.