INT28361

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1989
Last Reported 2011
Negated 11
Speculated 10
Reported most in Body
Documents 443
Total Number 452
Disease Relevance 384.86
Pain Relevance 28.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
colon 12
melanocyte 9
epithelial cells 8
T24 7
BxPC-3 5
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 272 100.00 Very High Very High Very High
qutenza 54 99.84 Very High Very High Very High
Inflammation 1083 99.68 Very High Very High Very High
Kinase C 23 99.44 Very High Very High Very High
withdrawal 36 99.28 Very High Very High Very High
Potency 42 99.20 Very High Very High Very High
cINOD 562 99.18 Very High Very High Very High
imagery 227 98.72 Very High Very High Very High
COX2 267 98.60 Very High Very High Very High
rheumatoid arthritis 193 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 14312 100.00 Very High Very High Very High
Apoptosis 4792 100.00 Very High Very High Very High
Aging 214 100.00 Very High Very High Very High
Aneuploidy 129 100.00 Very High Very High Very High
Shock 107 100.00 Very High Very High Very High
Li-fraumeni Syndrome 91 100.00 Very High Very High Very High
Tetraploidy 54 100.00 Very High Very High Very High
Pancreatic Cancer 1118 99.96 Very High Very High Very High
Chromosome Aberrations 155 99.96 Very High Very High Very High
Colon Cancer 1221 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lack of p53 expression in some cases of pancreatic adenocarcinoma may be due to different types of mutant proteins not detectable by the CM1 antibody.
Gene_expression (expression) of p53 associated with adenocarcinoma
1) Confidence 0.78 Published 1993 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 8218996 Disease Relevance 1.00 Pain Relevance 0.40
The expression of the p53 gene, therefore, appears increased in the majority of pancreatic adenocarcinomas while this is not observed in chronic pancreatitis or normal pancreatic tissue.
Gene_expression (expression) of p53 associated with adenocarcinoma and chronic pancreatitis
2) Confidence 0.78 Published 1993 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 8218996 Disease Relevance 1.13 Pain Relevance 0.40
Lee et al. combined multiple biomarkers and patient characteristics in Cox regression analysis and found that chromosome polyploidy, together with high p53 expression, LOH, and histology was the best predictor of cancer risk in a 10-y study of 70 patients with 22 cancer outcomes [13].
Gene_expression (expression) of p53 associated with polyploidy and cancer
3) Confidence 0.78 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808095 Disease Relevance 1.28 Pain Relevance 0.14
Sequencing of the p53-gene in 10 selected samples demonstrated that p53 overexpression correlates with the presence of a mutation.
Gene_expression (overexpression) of p53
4) Confidence 0.78 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.41 Pain Relevance 0.05
A limitation of our (and other's) interpretation of data is the heterogeneity of pigmentation, melanocyte colonization, and p53 overexpression in an individual tumor.
Gene_expression (overexpression) of p53 in pigmentation associated with cancer
5) Confidence 0.78 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.42 Pain Relevance 0.07
In our series of 49 BCC samples, we found several examples fitting into this pattern, but overall no significant correlation between p53 overexpression as an indication of p53 mutation and melanocyte colonization was found by statistical evaluation.
Gene_expression (overexpression) of p53 in melanocyte associated with basal cell carcinoma
6) Confidence 0.78 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.34 Pain Relevance 0.08
Surprisingly, we did not observe any correlation between melanocyte colonization and p53 overexpression, which is indicative of inactivating p53 mutations.
Gene_expression (overexpression) of p53 in melanocyte
7) Confidence 0.78 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC2989759 Disease Relevance 0.95 Pain Relevance 0
We further specifically evaluated associations with stage, histologic grade and TP53 overexpression of the tumor.


Gene_expression (overexpression) of TP53 associated with cancer
8) Confidence 0.77 Published 2007 Journal BMC Urol Section Body Doc Link PMC2018698 Disease Relevance 1.10 Pain Relevance 0.63
Ionizing radiation enhances the expression of the nonsteroidal anti-inflammatory drug-activated gene (NAG1) by increasing the expression of TP53 in human colon cancer cells.
Gene_expression (expression) of TP53 in colon associated with inflammation, colon cancer, cinod and cytokine
9) Confidence 0.75 Published 2006 Journal Radiat. Res. Section Title Doc Link 16435911 Disease Relevance 0.94 Pain Relevance 0.24
The transfection of a NAG1 siRNA into HCT116 cells suppressed radiation-induced apoptosis and inhibited the induction of NAG1 protein without altering the expression of TP53. a NAG1 luciferase promoter construct that included both of the TP53 binding sites, was activated by radiation in dose-dependent manner, while the promoters lacking one or both of the TP53 binding sites in the NAG1 promoter activity either was less responsive or did not respond.
Gene_expression (expression) of TP53 associated with apoptosis
10) Confidence 0.75 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.83 Pain Relevance 0.13
The expression of TP53 protein in HCT116 cells was increased after irradiation and was followed by an increase in the expression of NAG1 protein.
Gene_expression (expression) of TP53 protein
11) Confidence 0.75 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.93 Pain Relevance 0.16
The induction of apoptosis in cells of human colon cancer cell lines after gamma irradiation was investigated to determine whether apoptosis was mediated by TP53 and the subsequent expression of its downstream target, the NSAID-activated gene (NAG1).
Gene_expression (expression) of TP53 in colon associated with colon cancer, cinod and apoptosis
12) Confidence 0.75 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.67 Pain Relevance 0.17
After treatment with FLX, A549 and HT29 cells demonstrated concentration-dependent decrease in the expression of c-fos, c-jun, cyclin A, cyclin D1, and increased expression of p21(waf1) and p53 genes, which resulted in slowing of the cell cycle progression.
Gene_expression (expression) of p53 in HT29 associated with fluoxetine
13) Confidence 0.75 Published 2008 Journal Cancer Biol. Ther. Section Abstract Doc Link 18836303 Disease Relevance 0.72 Pain Relevance 0.85
Expression of dominant negative p53 in LNCaP cells blocked induction of PDF mRNA and protein demonstrating the requirement for functional p53 in PDF induction by these stimuli.
Gene_expression (Expression) of p53
14) Confidence 0.75 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19100681 Disease Relevance 0.89 Pain Relevance 0.24
DNA damage and hypoxia resulted in increased p53 protein accumulation indicating that PDF expression may be controlled by cellular levels of p53.
Gene_expression (levels) of p53 associated with hypoxia
15) Confidence 0.75 Published 2009 Journal Cancer Lett. Section Abstract Doc Link 19100681 Disease Relevance 0.86 Pain Relevance 0.23
The Ad-p53 can produce a good amount of p53 protein in target cells and achieve a variety of cellular responses.
Gene_expression (produce) of p53
16) Confidence 0.74 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.36 Pain Relevance 0
The Ad-p53 can produce a good amount of p53 protein in target cells and achieve a variety of cellular responses.
Gene_expression (produce) of p53
17) Confidence 0.74 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.36 Pain Relevance 0
Several lines of the experiments suggested that Ad-p53 produced better antitumor effects to tumors bearing mutated p53 genes than in those with the wild-type p53 gene (Cerrato et al 2001; Eisold et al 2004).
Gene_expression (produced) of p53 associated with cancer
18) Confidence 0.74 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.62 Pain Relevance 0
A number of clinical studies demonstrated that intratumoral injection of Ad-p53 resulted in vector-mediated p53 gene expression in various types of tumors and thus produced antitumor activities (Clayman et al 1998; Habib et al 1999; Swisher et al 1999; Singh et al 2002).
Gene_expression (expression) of p53 associated with cancer
19) Confidence 0.74 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.65 Pain Relevance 0
In contrast, adenoviruses (Ad) expressing the human wild-type p53 gene and Ad defective of the E1B-55 kDa molecule, both of which were originally developed and clinically examined for the efficacy in USA, have been admitted in China.
Gene_expression (expressing) of p53
20) Confidence 0.74 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761194 Disease Relevance 0.48 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox