INT28362

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Context Info
Confidence 0.75
First Reported 1981
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 29
Total Number 36
Disease Relevance 9.69
Pain Relevance 5.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (REG1A)
Anatomy Link Frequency
pancreas 5
spike 4
PSP 4
neurons 4
bands 2
REG1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 29 100.00 Very High Very High Very High
Neurotransmitter 25 99.92 Very High Very High Very High
Catecholamine 14 98.68 Very High Very High Very High
Action potential 35 98.56 Very High Very High Very High
Spinal cord 8 96.16 Very High Very High Very High
anesthesia 35 94.48 High High
Dopamine 3 94.44 High High
c fibre 11 93.68 High High
tetrodotoxin 23 93.48 High High
unmyelinated 4 91.44 High High
Disease Link Frequency Relevance Heat
Pancreatitis 42 100.00 Very High Very High Very High
Targeted Disruption 1 100.00 Very High Very High Very High
Injury 24 99.20 Very High Very High Very High
Fatigue 44 98.60 Very High Very High Very High
Paraparesis 2 97.52 Very High Very High Very High
Pancreatic Cancer 40 96.52 Very High Very High Very High
Obesity 87 96.28 Very High Very High Very High
Chronic Fatigue Syndrome 130 96.08 Very High Very High Very High
Stress 6 94.32 High High
Cancer 53 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: The level of pancreatic stone protein/regenerating protein (PSP/reg), a secretory protein produced in the pancreas, increases dramatically during pancreatic disease.
Gene_expression (produced) of reg in pancreas associated with pancreatitis
1) Confidence 0.75 Published 2009 Journal Crit. Care Med. Section Abstract Doc Link 19325491 Disease Relevance 0.27 Pain Relevance 0.09
In order to elucidate the characteristics of reg-protein, which is identical to pancreatic stone protein (PSP/reg-protein), and the relationship between the generation and evolution of chronic pancreatitis and the expression of PSP/reg-protein in the pancreas, we investigated the expression of PSP/reg-protein in normal and diseased human pancreatic tissues by immunohistochemistry.
Spec (investigated) Gene_expression (expression) of reg in pancreas associated with chronic pancreatitis
2) Confidence 0.75 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8454918 Disease Relevance 0.44 Pain Relevance 0.30
From the view of distribution and cellular localization, PSP/reg-protein was expressed more broadly and densely in chronic pancreatitis with mild to moderate injury than in the normal pancreas.
Gene_expression (expressed) of reg in pancreas associated with injury and chronic pancreatitis
3) Confidence 0.75 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8454918 Disease Relevance 0.70 Pain Relevance 0.35
Expression of this CD19+ B cell up-regulated gene set also discriminated ISF from controls at 0.05 confidence level.
Gene_expression (Expression) of reg in B cell associated with fatigue
4) Confidence 0.75 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.59 Pain Relevance 0.03
The PSP/reg-protein was expressed in all cases with normal pancreas or chronic pancreatitis, and in 70.6% of cases with pancreatic cancer.
Gene_expression (expressed) of reg in pancreas associated with pancreatic cancer and chronic pancreatitis
5) Confidence 0.75 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8454918 Disease Relevance 0.54 Pain Relevance 0.32
To date, however, there has been no study which examined the expression of REG I along with other differentiation markers in patients with chronic pancreatitis.
Spec (examined) Gene_expression (expression) of REG associated with chronic pancreatitis
6) Confidence 0.75 Published 2004 Journal Hepatogastroenterology Section Abstract Doc Link 15011837 Disease Relevance 0.10 Pain Relevance 0.10
CONCLUSIONS: The current study revealed that acinoductular cells characterized by dual expression of REG I and cytokeratin 19 also express insulin, chromogranin A and trypsin and therefore supports the hypothesis that transdifferentiation of fully differentiated (acinar) cells may be the main source of islet neogenesis in patients with chronic pancreatitis.
Gene_expression (expression) of REG
7) Confidence 0.75 Published 2004 Journal Hepatogastroenterology Section Body Doc Link 15011837 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVES: The level of pancreatic stone protein/regenerating protein (PSP/reg), a secretory protein produced in the pancreas, increases dramatically during pancreatic disease.
Gene_expression (protein) of reg in pancreas associated with pancreatitis
8) Confidence 0.65 Published 2009 Journal Crit. Care Med. Section Abstract Doc Link 19325491 Disease Relevance 0.26 Pain Relevance 0.09
Therefore, we aimed to determine whether PSP/reg is an acute-phase protein after nonpancreatic trauma.
Spec (whether) Gene_expression (/) of reg in PSP associated with injury
9) Confidence 0.65 Published 2009 Journal Crit. Care Med. Section Abstract Doc Link 19325491 Disease Relevance 0.36 Pain Relevance 0.09
Furthermore, knockout of Reg2?
Gene_expression (knockout) of Reg associated with targeted disruption
10) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.32 Pain Relevance 0.16
However, it is notable that production of catestatin itself (CgA(344)(-)(364)) utilizes more unusual cleavage sites at the NH(2)-terminal sides of downward arrow R and downward arrow RR basic residue sites, consistent with the cleavage specificities of the chromaffin granule cysteine protease "PTP" that participates in proenkephalin processing.
Gene_expression (production) of PTP in cleavage
11) Confidence 0.65 Published 2003 Journal Biochemistry Section Abstract Doc Link 12795588 Disease Relevance 0 Pain Relevance 0.04
It is concluded that ERCP/PTC has little value in detecting PTP.
Gene_expression (detecting) of PTP associated with pancreatitis
12) Confidence 0.65 Published 1995 Journal Chin. Med. J. Section Abstract Doc Link 8728942 Disease Relevance 0.57 Pain Relevance 0.13
In order to elucidate the characteristics of reg-protein, which is identical to pancreatic stone protein (PSP/reg-protein), and the relationship between the generation and evolution of chronic pancreatitis and the expression of PSP/reg-protein in the pancreas, we investigated the expression of PSP/reg-protein in normal and diseased human pancreatic tissues by immunohistochemistry.
Gene_expression (expression) of reg in PSP associated with chronic pancreatitis
13) Confidence 0.65 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8454918 Disease Relevance 0.37 Pain Relevance 0.24
In order to elucidate the characteristics of reg-protein, which is identical to pancreatic stone protein (PSP/reg-protein), and the relationship between the generation and evolution of chronic pancreatitis and the expression of PSP/reg-protein in the pancreas, we investigated the expression of PSP/reg-protein in normal and diseased human pancreatic tissues by immunohistochemistry.
Gene_expression (expression) of reg in PSP associated with chronic pancreatitis
14) Confidence 0.65 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8454918 Disease Relevance 0.37 Pain Relevance 0.24
The present results of double staining of REG I with cytokeratin 19, chromogranin A and insulin in the acinoductular cells indicate that REG I may be used as a marker for these cells.


Gene_expression (staining) of REG
15) Confidence 0.65 Published 2004 Journal Hepatogastroenterology Section Body Doc Link 15011837 Disease Relevance 0.05 Pain Relevance 0
Finally expression of the T regulatory set (FoxP3) was marginally repressed in LCA class 1 (p = 0.09) which contained 40% of the CFS subjects though no significant difference was found for the larger CFS group (p = 0.31).
Gene_expression (expression) of reg associated with chronic fatigue syndrome
16) Confidence 0.58 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.96 Pain Relevance 0
These findings suggest that mild to moderate injury to pancreatic tissue may stimulate the synthesis of PSP/reg-protein, whereas more severe injury tends to depress it.
Gene_expression (synthesis) of reg in PSP associated with injury
17) Confidence 0.58 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8454918 Disease Relevance 0.78 Pain Relevance 0.32
Contrary to reg1A, reg1B, reg3A and reg3G genes, all located on chromosome 2p12, reg4 is on chromosome 1p13.1-p12.
Gene_expression (is) of reg1A
18) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 0.59 Pain Relevance 0.04
The generation of these nonspiking network oscillations can be explained by the interaction between two synaptic mechanisms which do not produce discrete PSPs: neurotransmitter activation of bursting pacemaker oscillations in a single network neuron, and graded inhibition between network neurons.
Neg (not) Gene_expression (produce) of PSPs in neuron associated with neurotransmitter
19) Confidence 0.52 Published 1981 Journal J. Exp. Zool. Section Abstract Doc Link 7288387 Disease Relevance 0 Pain Relevance 0.53
The second pattern, found in seven neurons, was a long-lasting depolarization, only generated by C-strength stimuli, which continued from the early A-fiber evoked PSPs, peaked at 100-200 ms, and lasted for 300-500 ms, producing in six cases a continuous burst of action potentials with a maximal frequency at the expected latency of the C-afferent fiber input but with no clear A- and C-fiber evoked banding of the action potentials.
Gene_expression (producing) of PSPs in neurons associated with c fibre and action potential
20) Confidence 0.50 Published 1987 Journal J. Neurophysiol. Section Abstract Doc Link 3655877 Disease Relevance 0 Pain Relevance 0.91

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