INT28363

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Context Info
Confidence 0.45
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 8.66
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (NRSN1)
Anatomy Link Frequency
bands 2
CSF 1
T cells 1
NRSN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 4 90.56 High High
iatrogenic 6 85.08 High High
Dysuria 2 80.04 Quite High
cINOD 1 76.28 Quite High
headache 1 75.24 Quite High
medulla 2 47.92 Quite Low
Spinal cord 2 42.32 Quite Low
Demyelination 2 41.28 Quite Low
Potency 45 24.24 Low Low
cytokine 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 730 100.00 Very High Very High Very High
Paraparesis 2 97.52 Very High Very High Very High
Meningitis 3 97.40 Very High Very High Very High
Infection 237 95.76 Very High Very High Very High
Sprains And Strains 18 93.76 High High
Leukocytosis 3 91.88 High High
Lymphatic System Cancer 21 87.64 High High
Leukemia 45 87.28 High High
Viral Meningitis 1 86.56 High High
Spasticity 2 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antiviral effects of tenidap may be independent of its ability to reduce IL-6 production based on the observations that these effects were as prominent in IL-6 nonresponsive lines as in IL-6 responsive lines and that the inhibition of p24 production was not reversed by exogenous IL-6.
Gene_expression (production) of p24
1) Confidence 0.45 Published 1997 Journal J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. Section Abstract Doc Link 8989205 Disease Relevance 0.42 Pain Relevance 0.08
The Western blotting for HIV antibodies were positive for p24, p40 and p55, whereas that for gp 41 was negative in serum and CSF, suggesting that the meningitis occurred during the seroconversion in this patient.
Gene_expression (positive) of p24 in CSF associated with meningitis and acquired immune deficiency syndrome or hiv infection
2) Confidence 0.44 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 19348174 Disease Relevance 1.45 Pain Relevance 0.08
Serum and CSF antibodies to HTLV-I were positive at titers of X4,096 and X128, respectively by immunofluorescent assay, and specific IgG bands (p19, p24, p28 and p53 in serum and p19, p24, p53 in CSF) were detected by western blot analysis.
Gene_expression (detected) of p24 in bands
3) Confidence 0.42 Published 1989 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2752664 Disease Relevance 0.79 Pain Relevance 0.17
Serum and CSF antibodies to HTLV-I were positive at titers of X4,096 and X128, respectively by immunofluorescent assay, and specific IgG bands (p19, p24, p28 and p53 in serum and p19, p24, p53 in CSF) were detected by western blot analysis.
Gene_expression (detected) of p24 in bands
4) Confidence 0.18 Published 1989 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2752664 Disease Relevance 0.79 Pain Relevance 0.17
Viral replication was assessed by measuring p24 Gag production in cell-free supernatant with ELISA as described above.
Gene_expression (production) of p24
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.63 Pain Relevance 0
As shown in Figure 2, control T cells, either untransduced or transduced with a lentivirus expressing GFP alone, supported vigorous HIV-1 replication, with peak HIV-1 p24 antigen production exceeding 1000 ng/ml.
Gene_expression (production) of p24 in T cells associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.71 Pain Relevance 0
3 TCID50 per cell and then followed for expression of HIV-1 p24 Gag and GFP by flow cytometry.
Gene_expression (expression) of p24 associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.74 Pain Relevance 0
Coincidently, the staining of HIV-1 p24 Gag in the GFP+ population also decreased to 28% (Figure 3A).
Gene_expression (population) of p24 associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.72 Pain Relevance 0
As expected, cells expressing maC46 trapped the virions on the cell surface and became clearly p24-positive as detected by FACS, while only little p24 was detected on non-transduced cells (Figure 4B).
Neg (little) Gene_expression (detected) of p24
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.74 Pain Relevance 0
Expression of GFP and intracellular expression of HIV-1 p24 Gag was determined in transduced and infected CEMx174 and PM-1 populations using Perm & Fix reagents (Caltag Laboratories, Burlingame, CA) and staining with a PE-conjugated HIV p24 Gag antibody [37] (Clone KC57, Beckman Coulter, Brea, CA).
Gene_expression (expression) of p24 associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925957 Disease Relevance 0.33 Pain Relevance 0
In cell culture, transfection of provirus 395 yields reduced levels of Tax activity (~ 10 % of wild-type) although the amount of major capsid protein p24 expressed inside the cells and in the supernatant remains unaffected.
Gene_expression (expressed) of p24
11) Confidence 0.05 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.59 Pain Relevance 0
Antibodies recognizing epitopes from structural (envelope gp51 and capsid p24) and regulatory proteins (Tax and Rex) are synthesized at high titers.
Gene_expression (gp51) of p24
12) Confidence 0.05 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.76 Pain Relevance 0.04
The gag gene codes for the Pr44gag precursor, a polypeptide subsequently cleaved into the major non-glycosylated proteins of the viral particle (p15, p24 and p12) (Figure 2) [70,102-106].
Gene_expression (codes) of p24
13) Confidence 0.05 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0 Pain Relevance 0

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