INT283661

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Context Info
Confidence 0.02
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.22
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Pkn1) signal transduction (Pkn1) histone binding (Pkn1)
cytoplasmic membrane-bounded vesicle (Pkn1) plasma membrane (Pkn1) nucleus (Pkn1)
Anatomy Link Frequency
visceral 4
Pkn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 32 100.00 Very High Very High Very High
nud 82 98.20 Very High Very High Very High
agonist 6 95.20 Very High Very High Very High
Inflammation 90 84.80 Quite High
dorsal root ganglion 64 61.76 Quite High
Spinal cord 30 49.48 Quite Low
intrathecal 8 47.68 Quite Low
spastic colon 14 5.00 Very Low Very Low Very Low
Nav1.9 14 5.00 Very Low Very Low Very Low
isoflurane 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dyspepsia 82 98.20 Very High Very High Very High
INFLAMMATION 94 84.80 Quite High
Ganglion Cysts 64 61.76 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

44 32.32 Quite Low
Nociception 24 5.00 Very Low Very Low Very Low
Hypersensitivity 20 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Injury 8 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This data suggests that an increase in NMDA receptor activity due to the increased expression of the N1 cassette on CANs may be contributing to the visceral hypersensitivity response observed following RTX and TNBS treatment.
Positive_regulation (increase) of Gene_expression (expression) of N1 in visceral associated with nmda receptor and nud
1) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 0.62 Pain Relevance 0.60
This data suggests that an increase in NMDA receptor activity due to the increased expression of the N1 cassette on CANs may be contributing to the visceral hypersensitivity response observed following RTX and TNBS treatment.
Positive_regulation (increased) of Gene_expression (expression) of N1 in visceral associated with nmda receptor and nud
2) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2758842 Disease Relevance 0.61 Pain Relevance 0.59

General Comments

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