INT283683

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.80
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Id2) nucleus (Id2) protein complex (Id2)
cytoplasm (Id2)
Anatomy Link Frequency
nucleus 1
Id2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 72 83.68 Quite High
Spinal cord 16 80.84 Quite High
Mechanosensation 4 62.80 Quite High
Mechanotransduction 1 30.24 Quite Low
glial activation 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 164 70.44 Quite High
Apoptosis 53 68.00 Quite High
Injury 192 64.60 Quite High
Stress 18 59.08 Quite High
Wound Healing 100 58.80 Quite High
Polycystic Kidney Disease 62 56.24 Quite High
Shock 12 49.92 Quite Low
Death 24 42.08 Quite Low
Neurodegenerative Disease 8 30.16 Quite Low
Gliosis 8 28.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ID2 binds to bHLH transcription factors to inhibit their binding to E-box sequences, defined by the CANNTG motif (Yokota and Mori, 2002).
ID2 Binding (binds) of
1) Confidence 0.35 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.13 Pain Relevance 0.11
Genetic variability can explain the expression variability and strong linkage of Lpin1, Sox11, AL024210, and Id2 to their gene locations (cis-eQTLs).
Id2 Binding (linkage) of
2) Confidence 0.35 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.18 Pain Relevance 0.08
ID2 binds to bHLH transcription factors to inhibit their binding to E-box sequences, defined by the CANNTG motif (Yokota and Mori, 2002).
ID2 Binding (binding) of
3) Confidence 0.35 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.13 Pain Relevance 0.11
Alternatively, ID2 may stimulate proliferation by binding to the unphosphorylated Rb protein, allowing the release of the transcription factor E2F.
ID2 Binding (binding) of
4) Confidence 0.34 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.18 Pain Relevance 0
In PKD, when PC-1 or PC-2 are inactivated, Id2 translocates to the nucleus and interacts with E-protein, blocking its ability to induce growth-suppressive genes and resulting in increased activity of cdk2 and activation of cell proliferation; (2) PC-1 can activate the JAK/STAT signaling pathway, resulting in the induction of p21waf1 and cell cycle arrest in G0 and G1; (3) The intraflagellar transport component IFT88/polaris is capable of controlling G1/S transition of the cell cycle.
Id2 Binding (interacts) of in nucleus
5) Confidence 0.12 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.17 Pain Relevance 0.06

General Comments

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