INT283698

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 4.60
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sox11) translation factor activity, nucleic acid binding (Sox11) nucleus (Sox11)
translation (Sox11) DNA binding (Sox11) nucleic acid binding transcription factor activity (Sox11)
Anatomy Link Frequency
retinas 3
brain 1
striatum 1
forebrain 1
cerebellum 1
Sox11 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 162 96.04 Very High Very High Very High
Spinal cord 36 5.00 Very Low Very Low Very Low
glial activation 18 5.00 Very Low Very Low Very Low
peripheral neuropathy 9 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Glutamate 9 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 369 100.00 Very High Very High Very High
Injury 432 98.72 Very High Very High Very High
Diabetes Mellitus 9 97.52 Very High Very High Very High
Disease 18 95.24 Very High Very High Very High
Wound Healing 225 91.44 High High
Apoptosis 81 81.84 Quite High
Retinal Perforations 18 76.04 Quite High
Death 54 68.52 Quite High
Neurodegenerative Disease 18 56.60 Quite High
Gliosis 18 27.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our meta-analyses of publicly available data revealed that Lpin1, Id2, and Sox11 were differentially expressed during retinal development and trauma.
Gene_expression (expressed) of Sox11 associated with injury
1) Confidence 0.68 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.49 Pain Relevance 0.03
Genetic variability can explain the expression variability and strong linkage of Lpin1, Sox11, AL024210, and Id2 to their gene locations (cis-eQTLs).
Gene_expression (expression) of Sox11
2) Confidence 0.68 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.19 Pain Relevance 0.08
In forebrain, the expression variability of genes Lpin1, Id2, Sox11, and AL024210 mapped within the locus.
Gene_expression (expression) of Sox11 in forebrain
3) Confidence 0.68 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.39 Pain Relevance 0.05
Lpin1, Id2, and Sox11 were expressed in reactive glia of optic nerve heads (Yang et al. 2004) and diabetic retinas (Gerhardinger et al. 2005).
Gene_expression (expressed) of Sox11 in retinas associated with diabetes mellitus
4) Confidence 0.68 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.48 Pain Relevance 0.04
Using publicly available data on mouse retinal development (Dorrell et al. 2004), we determined that Lpin1, Id2, and Sox11 were expressed by the developing retina and had well defined patterns of expression (Fig. 3E; note that AL024210 levels were below detectable thresholds).
Gene_expression (expressed) of Sox11 in retina
5) Confidence 0.68 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.32 Pain Relevance 0.05
Sox11 expression in injured BXD retinas did not correlate with the segregating patterns of alleles.
Gene_expression (expression) of Sox11 in retinas
6) Confidence 0.52 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.55 Pain Relevance 0
Together these results documented that Lpin1, Id2, and Sox11 are candidate genes, because they displayed (1) cis-eQTLs in the brain, cerebellum, and striatum; (2) polymorphisms between parental strains; (3) differential expression during retinal development and retinal healing; and (4) moderate to high levels of expression in normal and reactive neural cells.
Gene_expression (expression) of Sox11 in brain associated with sprains and strains
7) Confidence 0.26 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.73 Pain Relevance 0.03
Together these results documented that Lpin1, Id2, and Sox11 are candidate genes, because they displayed (1) cis-eQTLs in the brain, cerebellum, and striatum; (2) polymorphisms between parental strains; (3) differential expression during retinal development and retinal healing; and (4) moderate to high levels of expression in normal and reactive neural cells.
Gene_expression (expression) of Sox11 in striatum associated with sprains and strains
8) Confidence 0.09 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.73 Pain Relevance 0.03
Together these results documented that Lpin1, Id2, and Sox11 are candidate genes, because they displayed (1) cis-eQTLs in the brain, cerebellum, and striatum; (2) polymorphisms between parental strains; (3) differential expression during retinal development and retinal healing; and (4) moderate to high levels of expression in normal and reactive neural cells.
Gene_expression (expression) of Sox11 in cerebellum associated with sprains and strains
9) Confidence 0.09 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.73 Pain Relevance 0.03

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