INT283698

Context Info Confidence 0.68 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 9 Disease Relevance 4.60 Pain Relevance 0.33

cell differentiation (Sox11) translation factor activity, nucleic acid binding (Sox11) nucleus (Sox11) translation (Sox11) DNA binding (Sox11) nucleic acid binding transcription factor activity (Sox11)

Anatomy Link Frequency retinas 3 brain 1 striatum 1 forebrain 1 cerebellum 1 Sox11 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 162 96.04 Spinal cord 36 5.00 glial activation 18 5.00 peripheral neuropathy 9 5.00 anesthesia 9 5.00 Glutamate 9 5.00 ischemia 9 5.00 Hippocampus 9 5.00 alcohol 9 5.00

Disease Link Frequency Relevance Heat Sprains And Strains 369 100.00 Injury 432 98.72 Diabetes Mellitus 9 97.52 Disease 18 95.24 Wound Healing 225 91.44 Apoptosis 81 81.84 Retinal Perforations 18 76.04 Death 54 68.52 Neurodegenerative Disease 18 56.60 Gliosis 18 27.68

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our meta-analyses of publicly available data revealed that Lpin1, Id2, and Sox11 were differentially expressed during retinal development and trauma.

Gene_expression (expressed) of Sox11 associated with injury

1) Confidence 0.68 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.49 Pain Relevance 0.03

Genetic variability can explain the expression variability and strong linkage of Lpin1, Sox11, AL024210, and Id2 to their gene locations (cis-eQTLs).

Gene_expression (expression) of Sox11

2) Confidence 0.68 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.19 Pain Relevance 0.08

In forebrain, the expression variability of genes Lpin1, Id2, Sox11, and AL024210 mapped within the locus.

Gene_expression (expression) of Sox11 in forebrain

3) Confidence 0.68 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.39 Pain Relevance 0.05

Lpin1, Id2, and Sox11 were expressed in reactive glia of optic nerve heads (Yang et al. 2004) and diabetic retinas (Gerhardinger et al. 2005).

Gene_expression (expressed) of Sox11 in retinas associated with diabetes mellitus

4) Confidence 0.68 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.48 Pain Relevance 0.04

Using publicly available data on mouse retinal development (Dorrell et al. 2004), we determined that Lpin1, Id2, and Sox11 were expressed by the developing retina and had well defined patterns of expression (Fig. 3E; note that AL024210 levels were below detectable thresholds).

Gene_expression (expressed) of Sox11 in retina

5) Confidence 0.68 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.32 Pain Relevance 0.05

Sox11 expression in injured BXD retinas did not correlate with the segregating patterns of alleles.

Gene_expression (expression) of Sox11 in retinas

6) Confidence 0.52 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.55 Pain Relevance 0

Together these results documented that Lpin1, Id2, and Sox11 are candidate genes, because they displayed (1) cis-eQTLs in the brain, cerebellum, and striatum; (2) polymorphisms between parental strains; (3) differential expression during retinal development and retinal healing; and (4) moderate to high levels of expression in normal and reactive neural cells.

Gene_expression (expression) of Sox11 in brain associated with sprains and strains

7) Confidence 0.26 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.73 Pain Relevance 0.03

Together these results documented that Lpin1, Id2, and Sox11 are candidate genes, because they displayed (1) cis-eQTLs in the brain, cerebellum, and striatum; (2) polymorphisms between parental strains; (3) differential expression during retinal development and retinal healing; and (4) moderate to high levels of expression in normal and reactive neural cells.

Gene_expression (expression) of Sox11 in striatum associated with sprains and strains

8) Confidence 0.09 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.73 Pain Relevance 0.03

Together these results documented that Lpin1, Id2, and Sox11 are candidate genes, because they displayed (1) cis-eQTLs in the brain, cerebellum, and striatum; (2) polymorphisms between parental strains; (3) differential expression during retinal development and retinal healing; and (4) moderate to high levels of expression in normal and reactive neural cells.

Gene_expression (expression) of Sox11 in cerebellum associated with sprains and strains

9) Confidence 0.09 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.73 Pain Relevance 0.03

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