INT283708

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Context Info
Confidence 0.71
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.72
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Id2) nucleus (Id2) protein complex (Id2)
cytoplasm (Id2)
Anatomy Link Frequency
nucleus 1
Id2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 18 91.36 High High
Mechanosensation 8 62.80 Quite High
Mechanotransduction 2 30.24 Quite Low
Somatostatin 8 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
glial activation 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 41 92.20 High High
Wound Healing 25 80.56 Quite High
Apoptosis 43 77.16 Quite High
Polycystic Kidney Disease 124 70.88 Quite High
Death 6 63.84 Quite High
Stress 8 59.08 Quite High
Cyst 64 57.44 Quite High
Disease 62 54.44 Quite High
Neurodegenerative Disease 2 51.92 Quite High
Congenital Anomalies 12 46.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lpin1, Sox11, AL024210, and Id2 had their gene location on chromosome 12 at 15.9, 23.9, 25.2, and 21.6, respectively (Fig. 3B).
Localization (location) of Id2
1) Confidence 0.71 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.37 Pain Relevance 0.05
The translocation of Id2 in cells with mutated polycystins is associated with downregulation of p21 expression, leading to an increase in CDK2 activity and cell cycle progression (Fig. 3).
Localization (translocation) of Id2
2) Confidence 0.27 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.18 Pain Relevance 0
In PKD, when PC-1 or PC-2 are inactivated, Id2 translocates to the nucleus and interacts with E-protein, blocking its ability to induce growth-suppressive genes and resulting in increased activity of cdk2 and activation of cell proliferation; (2) PC-1 can activate the JAK/STAT signaling pathway, resulting in the induction of p21waf1 and cell cycle arrest in G0 and G1; (3) The intraflagellar transport component IFT88/polaris is capable of controlling G1/S transition of the cell cycle.
Localization (translocates) of Id2 in nucleus
3) Confidence 0.23 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.17 Pain Relevance 0.06

General Comments

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