INT283731

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3, Creb1) nucleus (Trib3, Creb1) nucleoplasm (Creb1)
mitochondrion (Creb1) DNA binding (Creb1) enzyme binding (Trib3)
Anatomy Link Frequency
nucleus 1
Trib3 (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 29 94.40 High High
ischemia 67 88.88 High High
bDMF 24 83.24 Quite High
Hippocampus 22 79.52 Quite High
antagonist 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 59 88.88 High High
Cognitive Disorder 16 37.44 Quite Low
Apoptosis 5 22.48 Low Low
Targeted Disruption 26 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Fever 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings raise the possibility that EDC activation of extranuclear estrogen receptors may involve a nongenomic to genomic signaling cascade via kinase-induced activation of the transcription factor, CREB.
kinase Positive_regulation (activation) of CREB
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.16 Pain Relevance 0.16
Consequently, cAMP activates cAMP-dependent protein kinase (PKA), which may in turn activate cAMP response element binding protein (CREB), a transcription factor, in the nucleus.
kinase Positive_regulation (activate) of cAMP response element binding protein in nucleus
2) Confidence 0.00 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.28

General Comments

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