INT283735

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
cortex 1
Ptger2 (Mus musculus)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 58 100.00 Very High Very High Very High
nMDA receptor 4 86.16 High High
Hippocampus 16 77.60 Quite High
Glutamate 4 26.48 Quite Low
Pain 6 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
spinal dorsal horn 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 34 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Fever 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Hypercalcemia 2 5.00 Very Low Very Low Very Low
Dementia 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As mentioned above, we have shown that PGE2 increases the magnitude of both E- and L-LTP in the visual cortex (Akaneya and Tsumoto, 2006).
PGE2 Positive_regulation (increases) of L-LTP in cortex associated with long-term potentiation
1) Confidence 0.18 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.55
Taking these results together, we surmise that PGE2 has a direct action on E-LTP and an indirect action on L-LTP via the production of BDNF.


PGE2 Positive_regulation (action) of E-LTP associated with long-term potentiation
2) Confidence 0.13 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.37

General Comments

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