INT28376

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Context Info
Confidence 0.31
First Reported 1982
Last Reported 1989
Negated 2
Speculated 2
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
nerve 2
spleens 2
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 4 100.00 Very High Very High Very High
antagonist 2 99.80 Very High Very High Very High
Morphine 6 99.14 Very High Very High Very High
narcan 6 99.02 Very High Very High Very High
Enkephalin 30 97.88 Very High Very High Very High
opiate 4 83.44 Quite High
medulla 8 83.36 Quite High
Catecholamine 2 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have investigated the effect of fetal hypophysectomy on the localization of dopamine B-hydroxylase (DBH), phenylethanolamine N-methyltransferase (PNMT) and enkephalin-containing peptides in the fetal sheep adrenal, using immunocytochemical techniques.
Spec (investigated) Regulation (effect) of Localization (localization) of dopamine B-hydroxylase associated with dopamine and enkephalin
1) Confidence 0.31 Published 1989 Journal J. Endocrinol. Section Abstract Doc Link 2754370 Disease Relevance 0 Pain Relevance 0.37
We have investigated the effect of fetal hypophysectomy on the localization of dopamine B-hydroxylase (DBH), phenylethanolamine N-methyltransferase (PNMT) and enkephalin-containing peptides in the fetal sheep adrenal, using immunocytochemical techniques.
Spec (investigated) Regulation (effect) of Localization (localization) of DBH associated with dopamine and enkephalin
2) Confidence 0.31 Published 1989 Journal J. Endocrinol. Section Abstract Doc Link 2754370 Disease Relevance 0 Pain Relevance 0.37
Perfusion of spleens with naloxone (10(-6) M), a pure narcotic antagonist, did not alter the release of endogenous norepinephrine, total 3H, DBH or perfusion pressure.
Neg (not) Regulation (alter) of Localization (release) of DBH in spleens associated with antagonist and narcan
3) Confidence 0.12 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6281410 Disease Relevance 0 Pain Relevance 1.12
However, perfusion of spleens with morphine (10(-7)-10(-4) M) produced no significant changes in the release of endogenous norepinephrine, total 3H or DBH after nerve stimulation at 5 Hz.
Neg (no) Regulation (changes) of Localization (release) of DBH in nerve associated with morphine
4) Confidence 0.12 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6281410 Disease Relevance 0 Pain Relevance 1.00

General Comments

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