INT2838

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Context Info
Confidence 0.67
First Reported 1979
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 27
Total Number 28
Disease Relevance 6.25
Pain Relevance 6.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)
Anatomy Link Frequency
plasma 6
uterine 4
embryos 2
PAG 2
PGE2 2
Oxt (Mus musculus)
Pain Link Frequency Relevance Heat
epidural 17 100.00 Very High Very High Very High
anesthesia 3 100.00 Very High Very High Very High
withdrawal 16 99.78 Very High Very High Very High
antagonist 50 99.74 Very High Very High Very High
Analgesic 8 99.62 Very High Very High Very High
Acupuncture 7 99.56 Very High Very High Very High
cannabis 3 99.56 Very High Very High Very High
Opioid 27 99.42 Very High Very High Very High
analgesia 20 98.70 Very High Very High Very High
tolerance 13 96.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Opiate Addiction 8 99.96 Very High Very High Very High
Asthma 68 99.70 Very High Very High Very High
Urological Neuroanatomy 5 99.60 Very High Very High Very High
Hypernatremia 2 99.06 Very High Very High Very High
Prolonged Pregnancy 2 99.00 Very High Very High Very High
Stress 4 98.72 Very High Very High Very High
Reprotox - General 1 12 98.18 Very High Very High Very High
Hemorrhage 2 96.12 Very High Very High Very High
Fever 2 95.72 Very High Very High Very High
Drug Dependence 19 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced sodium appetite and increased oxytocin gene expression in mutant mice lacking beta-endorphin.
Positive_regulation (increased) of Gene_expression (expression) of oxytocin
1) Confidence 0.67 Published 2003 Journal Neuroscience Section Title Doc Link 14580937 Disease Relevance 0.22 Pain Relevance 0.27
[Misoprostol and oxytocin in induction of labour in women with prolonged pregnancy--safety and effectiveness comparison].
Positive_regulation (induction) of Gene_expression ([Misoprostol) of oxytocin associated with prolonged pregnancy
2) Confidence 0.50 Published 2001 Journal Wiad. Lek. Section Title Doc Link 11928554 Disease Relevance 0.27 Pain Relevance 0.08
There was a significant reduction in the requirement for oxytocin augmentation in women treated with PGE2: primigravidae, odds ratio (OR), 0.27 and 95% confidence interval (CI), 0.12-0.61; multiparae, OR, 0.19 and 95% CI, 0.08-0.45.
Positive_regulation (requirement) of Gene_expression (augmentation) of oxytocin in PGE2
3) Confidence 0.49 Published 1995 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 7774735 Disease Relevance 0 Pain Relevance 0.50
There was no significant increase in plasma oxytocin levels during this study in either test responders or nonresponders.
Neg (no) Positive_regulation (increase) of Gene_expression (levels) of oxytocin in plasma
4) Confidence 0.49 Published 1986 Journal Am J Perinatol Section Abstract Doc Link 3942612 Disease Relevance 0.43 Pain Relevance 0.17
However, the requirement for oxytocin augmentation during the first and second stages of labour was significantly less in the lignocaine group (p = 0.004).
Positive_regulation (requirement) of Gene_expression (augmentation) of oxytocin
5) Confidence 0.49 Published 1992 Journal Anaesthesia Section Abstract Doc Link 1489026 Disease Relevance 0.26 Pain Relevance 0.29
Taken together, our data suggest that the reduced sodium ingestion observed in beta-endorphin deficient mice could be due to a higher expression of the OT gene.
Positive_regulation (due) of Gene_expression (expression) of OT gene
6) Confidence 0.49 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.20 Pain Relevance 0
Moreover, beta-endorphin mutated mice have similar higher levels of OT mRNA expression after the different conditions analyzed: basal, control or experimental, compared with WT mice.
Positive_regulation (levels) of Gene_expression (expression) of OT
7) Confidence 0.49 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.30 Pain Relevance 0.11
Augmentation of labour: does oxytocin titration to achieve preset active contraction area values produce better obstetric outcome?
Positive_regulation (titration) of Gene_expression (titration) of oxytocin
8) Confidence 0.48 Published 1989 Journal Asia Oceania J Obstet Gynaecol Section Title Doc Link 2696457 Disease Relevance 0.07 Pain Relevance 0.06
The 100 and 50 microg groups had similar mean Bishop's scores at induction (4.0+/-2.3 vs 4.1+/-2.2, p=0.87), rates of nulliparity, use of epidural anesthesia, and oxytocin augmentation.
Positive_regulation (induction) of Gene_expression (augmentation) of oxytocin associated with anesthesia and epidural
9) Confidence 0.48 Published 2001 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 11561740 Disease Relevance 0.08 Pain Relevance 0.15
The progesterone antagonist onapristone increases the effectiveness of oxytocin to produce delivery without changing the myometrial oxytocin receptor concentrations.
Positive_regulation (increases) of Neg (without) Gene_expression (produce) of oxytocin associated with antagonist
10) Confidence 0.47 Published 1991 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 1661070 Disease Relevance 0.08 Pain Relevance 0.17
Sixty-nine primiparae were assigned to four groups: mothers having received oxytocin infusion during labor (OT iv group, n = 9), mothers having received epidural analgesia with/without oxytocin infusion (EDA group, n = 23), mothers having received 10 iU oxytocin intramuscularly after birth (OT im group, n = 15) and mothers having received none of these treatments (unmedicated group, n = 22).
Positive_regulation (received) of Gene_expression (infusion) of oxytocin associated with epidural and analgesia
11) Confidence 0.47 Published 2008 Journal Arch Womens Ment Health Section Abstract Doc Link 18726143 Disease Relevance 0.20 Pain Relevance 0.40
[Different labour behaviours following induction, using oxytocin and prostaglandin F2 alpha (Enzaprost) (author's transl)].
Positive_regulation (induction) of Gene_expression (using) of oxytocin
12) Confidence 0.43 Published 1979 Journal Zentralbl Gynakol Section Title Doc Link 547604 Disease Relevance 0.09 Pain Relevance 0.09
Does early administration of epidural analgesia affect obstetric outcome in nulliparous women who are receiving intravenous oxytocin?
Positive_regulation (intravenous) of Gene_expression (intravenous) of oxytocin associated with epidural and analgesia
13) Confidence 0.42 Published 1994 Journal Anesthesiology Section Title Doc Link 8010465 Disease Relevance 0 Pain Relevance 0.43
In all women, oxytocin variability and the rise of prolactin levels between 0 and 20 minutes correlated significantly with median oxytocin and prolactin levels.
Positive_regulation (median) of Gene_expression (levels) of oxytocin
14) Confidence 0.41 Published 2009 Journal Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine Section Body Doc Link 19210132 Disease Relevance 0 Pain Relevance 0
We found no significant difference in the percentage of
               oxytocin use attributable to the application of the algorithm (difference=0.3, 95%
               confidence interval ?
Positive_regulation (percentage) of Gene_expression (use) of oxytocin
15) Confidence 0.41 Published 2008 Journal BMJ : British Medical Journal Section Body Doc Link PMC2601030 Disease Relevance 0 Pain Relevance 0
Our studies revealed that detectable oxytocin levels were found in the BAL fluid in both cohorts; however, in stable asthma, there was no increase in oxytocin levels in BAL fluid.
Neg (no) Positive_regulation (increase) of Gene_expression (levels) of oxytocin associated with asthma
16) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.29 Pain Relevance 0.04
As shown in Table 2, oxytocin levels are present in BAL fluid from both normal subjects and those with asthma (n = 10 in each group) but no significant changes were detected between these cohorts.
Positive_regulation (present) of Gene_expression (levels) of oxytocin associated with asthma
17) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2922094 Disease Relevance 0.37 Pain Relevance 0.06
METHODS: In a descriptive comparative study plasma oxytocin and prolactin concentrations were measured in response to suckling during the second day postpartum in women who had received intravenous intrapartum oxytocin (n = 8), intramuscular postpartum oxytocin (n = 13), or epidural analgesia, either with (n = 14) or without (n = 6) intrapartum oxytocin infusion, and women who received none of these interventions (n = 20).
Positive_regulation (response) of Gene_expression (measured) of oxytocin in plasma
18) Confidence 0.36 Published 2009 Journal Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine Section Body Doc Link 19210132 Disease Relevance 0.09 Pain Relevance 0
Immunocytochemistry reveals OT-GKR in developing hearts
Positive_regulation (reveals) of Gene_expression (reveals) of OT in hearts
19) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.07 Pain Relevance 0.06
Immunocytochemistry of mouse embryos (embryonic day 15) showed cardiac OT-GKR accumulation and OTR expression.
Positive_regulation (accumulation) of Gene_expression (expression) of OT in embryos
20) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0.08

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