INT283841

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4)
kinase activity (Insrr) cytoplasm (Dlg4)
Anatomy Link Frequency
neurons 2
Dlg4 (Mus musculus)
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 4 95.84 Very High Very High Very High
Dopamine 22 95.56 Very High Very High Very High
depression 6 72.52 Quite High
cytokine 6 67.92 Quite High
monoamine 26 5.00 Very Low Very Low Very Low
Eae 24 5.00 Very Low Very Low Very Low
Hippocampus 14 5.00 Very Low Very Low Very Low
nMDA receptor 8 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Pyramidal cell 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 18 92.84 High High
Targeted Disruption 220 92.02 High High
Depression 6 72.52 Quite High
Manic Depressive Disorder 4 71.88 Quite High
Schizophrenia 26 71.16 Quite High
Cognitive Disorder 24 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 8 5.00 Very Low Very Low Very Low
Mental Disorders 8 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These knockout mice showed (a) behavioral abnormalities similar to those described in psychiatric disorders, which were ameliorated by typical or atypical antipsychotics, (b) altered dopamine and serotonin levels in the brain, (c) decreases in spine density in neurons of the prefrontal cortex, (d) reductions in the protein levels of the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor and post-synaptic protein-95 (PSD-95), (e) decreases in the EGF receptor, and in the calcium/calmodulin-dependent protein kinase II (CaMK II) signal cascade.
PSD-95 Negative_regulation (decreases) of receptor in neurons associated with targeted disruption, dopamine, congenital anomalies and serotonin
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759290 Disease Relevance 0.47 Pain Relevance 0.17
These knockout mice showed (a) behavioral abnormalities similar to those described in psychiatric disorders, which were ameliorated by typical or atypical antipsychotics, (b) altered dopamine and serotonin levels in the brain, (c) decreases in spine density in neurons of the prefrontal cortex, (d) reductions in the protein levels of the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor and post-synaptic protein-95 (PSD-95), (e) decreases in the EGF receptor, and in the calcium/calmodulin-dependent protein kinase II (CaMK II) signal cascade.
protein-95 Negative_regulation (decreases) of receptor in neurons associated with targeted disruption, dopamine, congenital anomalies and serotonin
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759290 Disease Relevance 0.48 Pain Relevance 0.17

General Comments

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