INT28387

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Context Info
Confidence 0.40
First Reported 1985
Last Reported 1994
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.28
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
gonadal 2
ovaries 2
Pomc (Rattus norvegicus)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 100.00 Very High Very High Very High
Neuropeptide 6 100.00 Very High Very High Very High
opiate 4 100.00 Very High Very High Very High
excitatory amino acid 2 100.00 Very High Very High Very High
narcan 4 99.72 Very High Very High Very High
agonist 3 99.52 Very High Very High Very High
Endogenous opioid 1 99.32 Very High Very High Very High
Clonidine 4 98.80 Very High Very High Very High
Intracerebroventricular 1 79.00 Quite High
Opioid 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Body Weight 6 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of clonidine, a central alpha-adrenergic agonist, on the suppression of LH release induced by beta-endorphin or FK33-824, an endogenous opioid peptide or its synthetic analog, was investigated in castrated male rats, with or without pretreatment with reserpine.
beta-endorphin Positive_regulation (induced) of Localization (release) of LH associated with endogenous opioid, agonist and clonidine
1) Confidence 0.40 Published 1985 Journal Endocrinol. Jpn. Section Abstract Doc Link 2936599 Disease Relevance 0 Pain Relevance 0.52
The objectives of the present study were to determine: (1) if this paradoxical effect of morphine on LH secretion could be antagonized by naloxone; (2) whether beta-endorphin also stimulated LH secretion under similar conditions; (3) what influence, if any, the ovaries have on the expression of this opiate-induced LH secretion, and (4) whether this paradoxical effect of morphine extended to prolactin (PRL) secretion.
beta-endorphin Spec (whether) Positive_regulation (stimulated) of Localization (secretion) of LH in ovaries associated with narcan, opiate and morphine
2) Confidence 0.20 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2755561 Disease Relevance 0.28 Pain Relevance 0.80
The hypothalamic peptides, beta-endorphin, neuropeptide K and interleukin-1 beta, and the opiate morphine, enhance the excitatory amino acid-induced LH release under the influence of gonadal steroids.
beta-endorphin Positive_regulation (enhance) of Localization (release) of LH in gonadal associated with neuropeptide, opiate, excitatory amino acid and morphine
3) Confidence 0.10 Published 1994 Journal J. Neuroendocrinol. Section Title Doc Link 7827626 Disease Relevance 0 Pain Relevance 0.74

General Comments

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