INT28389

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Context Info
Confidence 0.37
First Reported 1984
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.40
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptpra)
Anatomy Link Frequency
brain 3
plasma 1
CVLM 1
Ptpra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 20 100.00 Very High Very High Very High
Dopamine 12 99.84 Very High Very High Very High
antagonist 2 99.20 Very High Very High Very High
tetrodotoxin 1 98.86 Very High Very High Very High
Morphine 39 98.64 Very High Very High Very High
withdrawal 9 98.20 Very High Very High Very High
medulla 6 96.66 Very High Very High Very High
narcan 4 90.36 High High
tolerance 3 82.40 Quite High
Opioid 1 35.12 Quite Low
Disease Link Frequency Relevance Heat
Stress 3 93.04 High High
Pressure Volume 2 Under Development 1 88.72 High High
Heart Rate Under Development 2 86.88 High High
Hypertension 1 47.68 Quite Low
Cv Unclassified Under Development 1 41.12 Quite Low
Weight Loss 1 32.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify the effects of withdrawal from chronic morphine treatment on cerebral noradrenaline (NA) turnover, we have measured the alpha-methyl-p-tyrosine (alpha MT)-induced depletion of NA in five brain areas of male Wistar rats given morphine twice daily for 40 or 60 days.
Negative_regulation (depletion) of alpha-methyl-p-tyrosine in brain associated with noradrenaline, withdrawal and morphine
1) Confidence 0.37 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6541758 Disease Relevance 0 Pain Relevance 1.01
To clarify the effects of withdrawal from chronic morphine treatment on cerebral dopamine (DA) turnover, we have measured the alpha-methyl-p-tyrosine (alpha MT)-induced depletion of DA in five brain areas of male Wistar rats given morphine twice daily for 40 or 60 days.
Negative_regulation (depletion) of alpha-methyl-p-tyrosine in brain associated with dopamine, withdrawal and morphine
2) Confidence 0.37 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6541759 Disease Relevance 0 Pain Relevance 1.13
The main purpose of these experiments was to study whether the morphine-induced changes in cerebral noradrenaline (NA) turnover differ between various brain areas of male Wistar rats assessed by the alpha-methyl-p-tyrosine (alpha MT)-induced NA depletion.
Negative_regulation (depletion) of alpha-methyl-p-tyrosine in brain associated with noradrenaline and morphine
3) Confidence 0.33 Published 1989 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2755921 Disease Relevance 0 Pain Relevance 0.80
By microdialysis in the unilateral caudal ventrolateral medulla (CVLM) of anesthetized rats, the spontaneous L-3,4-dihydroxyphenylalanine (L-DOPA) release was in part tetrodotoxin-sensitive or Ca(2+)-dependent and was abolished by i.p. alpha-methyl-p-tyrosine (alpha-MPT), a tyrosine hydroxylase inhibitor.
Negative_regulation (inhibitor) of alpha-methyl-p-tyrosine in CVLM associated with tetrodotoxin and medulla
4) Confidence 0.06 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8264947 Disease Relevance 0.18 Pain Relevance 0.38
The alpha 1-adrenoceptor antagonist, prazosin and the tyrosine hydroxylase inhibitor, alpha-methyl-para-tyrosine (alpha-MPT), increased the hypothalamic corticotrophin releasing factor (CRF) content and the plasma corticotrophin (ACTH) concentration and exaggerated the HPA response to stress.
Negative_regulation (inhibitor) of alpha-methyl-para-tyrosine in plasma associated with stress and antagonist
5) Confidence 0.05 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2821423 Disease Relevance 0.23 Pain Relevance 0.38

General Comments

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