INT283890

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 1.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CALD1) plasma membrane (CALD1) cytoskeleton (CALD1)
cytoplasm (CALD1)
Anatomy Link Frequency
myometrium 3
CALD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanotransduction 40 5.00 Very Low Very Low Very Low
imagery 20 5.00 Very Low Very Low Very Low
Dismenorea 20 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 470 92.12 High High
Pre-term Labor 60 81.56 Quite High
Apoptosis 10 49.20 Quite Low
Colon Cancer 10 43.92 Quite Low
Polyhydramnios 30 5.00 Very Low Very Low Very Low
Dysmenorrhea 20 5.00 Very Low Very Low Very Low
Hypertension 20 5.00 Very Low Very Low Very Low
Endometriosis (extended) 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate that the Ca requirement for activation of the contractile filaments in human myometrium increases with caldesmon protein content during gestation and that an increase in caldesmon phosphorylation can reverse this inhibitory effect during labor.
Phosphorylation (phosphorylation) of caldesmon in myometrium
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759504 Disease Relevance 0.32 Pain Relevance 0
We found (Fig. 1C) that h-CaD phosphorylation at an ERK specific site (Ser 789) increases significantly in human myometrial tissue from pregnant women in labor (1.97±0.24 vs. 1.01±0.27 in NP group) but not from those not in labor (1.3±0.39).
Phosphorylation (phosphorylation) of h-CaD
2) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
Although tyrosine phosphorylation of l-CaD has been described, to the best of our knowledge, h-CaD has not been reported to be directly tyrosine phosphorylated.
Phosphorylation (phosphorylation) of l-CaD
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.55 Pain Relevance 0
Gestation- dependent increases in h-CaD phosphorylation in human myometrium
Phosphorylation (phosphorylation) of h-CaD in myometrium
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
Whether this ERK-mediated phosphorylation of h-CaD during labor occurs in the human has not been reported.
Phosphorylation (phosphorylation) of h-CaD
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
Stretch of human myometrium causes increased ERK activation and h-CaD phosphorylation
Phosphorylation (phosphorylation) of h-CaD in myometrium
6) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
Although tyrosine phosphorylation of l-CaD has been described, to the best of our knowledge, h-CaD has not been reported to be directly tyrosine phosphorylated.
Phosphorylation (phosphorylated) of h-CaD
7) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.54 Pain Relevance 0
Although tyrosine phosphorylation of l-CaD has been described, to the best of our knowledge, h-CaD has not been reported to be directly tyrosine phosphorylated.
Phosphorylation (phosphorylation) of l-CaD
8) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.55 Pain Relevance 0
To test whether stretch itself directly regulates ERK-dependent h-CaD phosphorylation, we exposed human myometrial strips to in vitro stretch.
Phosphorylation (phosphorylation) of h-CaD
9) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
The increased h-CaD phosphorylation seen at the end of term could be due to many factors including hormonal factors as well as the increased stretch of the myometrial wall.
Phosphorylation (phosphorylation) of h-CaD
10) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0

General Comments

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