INT283891

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.36
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (APOA5) transport (APOA5) extracellular space (APOA5)
small molecule metabolic process (APOA5) extracellular region (APOA5) enzyme binding (APOA5)
Anatomy Link Frequency
smooth muscle 2
cortex 2
APOA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 5 83.36 Quite High
Dismenorea 10 79.20 Quite High
Mechanotransduction 20 53.12 Quite High
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 235 97.24 Very High Very High Very High
Polyhydramnios 15 89.88 High High
Pre-term Labor 30 86.32 High High
Dysmenorrhea 10 79.20 Quite High
Apoptosis 5 21.64 Low Low
Colon Cancer 5 16.36 Low Low
Hypertension 10 5.00 Very Low Very Low Very Low
Endometriosis (extended) 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study we report that expression levels of a newly identified smooth muscle protein, SmAV, increase significantly during pregnancy.
Positive_regulation (increase) of Gene_expression (expression) of SmAV in smooth muscle
1) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.60 Pain Relevance 0.22
We have previously shown in the timed pregnant rat model that ERK is targeted to the cell cortex in late term pregnancy [6] and the upregulation of SmAV expression may be one factor that contributes to the targeting of ERK to focal adhesions in a gestation-dependent manner.
Positive_regulation (upregulation) of Gene_expression (expression) of SmAV in cortex associated with adhesions
2) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.48 Pain Relevance 0
To explore the possible function of the gestation-induced increases in SmAV expression in the human, we probed anti-phosphotyrosine immunoprecipitates of control and stretched human myometrial strips (term pregnant, stretched 2x slack length for 7 min) for SmAV.
Spec (possible) Positive_regulation (increases) of Gene_expression (expression) of SmAV
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
Gestational upregulation of SmAV expression implies a possible role of this protein during pregnancy.
Positive_regulation (upregulation) of Gene_expression (expression) of SmAV
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
Gestation-dependent increase in SmAV expression in both human and rat myometrial tissues
Positive_regulation (increase) of Gene_expression (expression) of SmAV
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.28 Pain Relevance 0

General Comments

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