INT283897

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Context Info
Confidence 0.32
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.32
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CALD1) plasma membrane (CALD1) cytoskeleton (CALD1)
cytoplasm (CALD1)
Anatomy Link Frequency
myometrium 8
CALD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanotransduction 28 5.00 Very Low Very Low Very Low
imagery 14 5.00 Very Low Very Low Very Low
Dismenorea 14 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 329 85.28 High High
Pre-term Labor 42 82.04 Quite High
Polyhydramnios 21 5.00 Very Low Very Low Very Low
Dysmenorrhea 14 5.00 Very Low Very Low Very Low
Hypertension 14 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low
Colon Cancer 7 5.00 Very Low Very Low Very Low
Endometriosis (extended) 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate that the Ca requirement for activation of the contractile filaments in human myometrium increases with caldesmon protein content during gestation and that an increase in caldesmon phosphorylation can reverse this inhibitory effect during labor.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of caldesmon in myometrium
1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2759504 Disease Relevance 0.32 Pain Relevance 0
Whether this ERK-mediated phosphorylation of h-CaD during labor occurs in the human has not been reported.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of h-CaD
2) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
Gestation- dependent increases in h-CaD phosphorylation in human myometrium
Positive_regulation (increases) of Phosphorylation (phosphorylation) of h-CaD in myometrium
3) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
We found (Fig. 1C) that h-CaD phosphorylation at an ERK specific site (Ser 789) increases significantly in human myometrial tissue from pregnant women in labor (1.97±0.24 vs. 1.01±0.27 in NP group) but not from those not in labor (1.3±0.39).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of h-CaD
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
Stretch of human myometrium causes increased ERK activation and h-CaD phosphorylation
Positive_regulation (causes) of Phosphorylation (phosphorylation) of h-CaD in myometrium
5) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
Stretch of human myometrium causes increased ERK activation and h-CaD phosphorylation
Positive_regulation (activation) of Phosphorylation (phosphorylation) of h-CaD in myometrium
6) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
The increased h-CaD phosphorylation seen at the end of term could be due to many factors including hormonal factors as well as the increased stretch of the myometrial wall.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of h-CaD
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0

General Comments

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