INT28390

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Context Info
Confidence 0.36
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.13
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mt1a) nucleus (Mt1a) intracellular (Mt1a)
lysosome (Mt1a) cytoplasm (Mt1a)
Anatomy Link Frequency
brain 1
Mt1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Thalamus 144 100.00 Very High Very High Very High
noradrenaline 10 100.00 Very High Very High Very High
lidocaine 74 99.82 Very High Very High Very High
Morphine 13 96.94 Very High Very High Very High
Bile 2 96.60 Very High Very High Very High
amygdala 4 95.28 Very High Very High Very High
Dynorphin 6 94.56 High High
Anterior cingulate cortex 178 88.44 High High
Central nervous system 2 87.52 High High
withdrawal 2 82.48 Quite High
Disease Link Frequency Relevance Heat
Nociception 62 98.68 Very High Very High Very High
Pain 38 81.32 Quite High
Cognitive Disorder 4 64.00 Quite High
Hepatitis 1 41.76 Quite Low
Sprains And Strains 1 40.04 Quite Low
Shock 12 27.48 Quite Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The output of Cd stimulated by TTM injection may be related to MT reduction resulting from removal of MT-bound Cu.
Negative_regulation (reduction) of MT
1) Confidence 0.36 Published 1997 Journal Toxicology Section Abstract Doc Link 9160108 Disease Relevance 0 Pain Relevance 0.12
No effect was observed after subcutaneous administration of N-MT Dyn A.
Negative_regulation (administration) of N-MT
2) Confidence 0.25 Published 2004 Journal AAPS J Section Abstract Doc Link 15760101 Disease Relevance 0 Pain Relevance 0.50
The main purpose of these experiments was to study whether the morphine-induced changes in cerebral noradrenaline (NA) turnover differ between various brain areas of male Wistar rats assessed by the alpha-methyl-p-tyrosine (alpha MT)-induced NA depletion.
Negative_regulation (depletion) of alpha MT in brain associated with noradrenaline and morphine
3) Confidence 0.25 Published 1989 Journal Pharmacol. Toxicol. Section Abstract Doc Link 2755921 Disease Relevance 0 Pain Relevance 0.80
The present study did not include pretraining lidocaine infusions because lidocaine-induced inactivation of the MT can last for approximately 30 min.
Negative_regulation (inactivation) of MT associated with thalamus and lidocaine
4) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.48 Pain Relevance 0.97
Another possible explanation is that inactivation of the MT interrupts the consolidation of nociceptive memory.
Negative_regulation (inactivation) of MT associated with nociception and thalamus
5) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2917407 Disease Relevance 0.65 Pain Relevance 1.01

General Comments

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