INT283934

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.06
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Phax, Mapk14) nucleus (Phax, Mapk14) nucleoplasm (Phax)
mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
Anatomy Link Frequency
spinal cord 4
Phax (Rattus norvegicus)
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 46 99.68 Very High Very High Very High
allodynia 30 98.48 Very High Very High Very High
c fibre 34 96.48 Very High Very High Very High
Dorsal horn 10 80.64 Quite High
Sciatic nerve 20 68.76 Quite High
ectopic activity 4 54.88 Quite High
Spinal nerve ligature 6 53.68 Quite High
qutenza 10 40.48 Quite Low
withdrawal 16 26.28 Quite Low
Hyperalgesia 8 20.08 Low Low
Disease Link Frequency Relevance Heat
Nervous System Injury 190 100.00 Very High Very High Very High
Neuropathic Pain 78 98.48 Very High Very High Very High
Nociception 40 98.04 Very High Very High Very High
Injury 20 86.16 High High
Hyperalgesia 8 20.08 Low Low
Pain 24 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Ganglion Cysts 2 5.00 Very Low Very Low Very Low
Post Operative Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data show that RTX fails to inhibit SNI-induced microglial proliferation and p38 activation in the spinal cord, suggesting that a selective nociceptive block (primarily targeting C-fibers) is not sufficient to prevent microglial activation.
RTX Negative_regulation (inhibit) of Positive_regulation (activation) of p38 in spinal cord associated with nociception, c fibre, nervous system injury and spinal cord
1) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 0.83 Pain Relevance 0.88
Bupivacaine but not RTX reduces p38 activation in the spinal cord after SNI
RTX Negative_regulation (reduces) of Positive_regulation (activation) of p38 in spinal cord associated with nervous system injury and spinal cord
2) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.23 Pain Relevance 0.21

General Comments

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