INT283975

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Context Info
Confidence 0.38
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.99
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCH1) small molecule metabolic process (GCH1) nucleolus (GCH1)
nucleus (GCH1) protein complex assembly (GCH1) protein complex (GCH1)
GCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GCH1 32 100.00 Very High Very High Very High
Tetrahydrobiopterin 6 99.84 Very High Very High Very High
Pain 80 95.64 Very High Very High Very High
opioid receptor 6 78.24 Quite High
opiate 2 73.60 Quite High
Lasting pain 10 66.40 Quite High
IPN 2 53.68 Quite High
Neurotransmitter 2 50.92 Quite High
Fibrositis 44 50.00 Quite Low
Pain score 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 90 95.64 Very High Very High Very High
Pancreatitis 2 90.76 High High
Hyperalgesia 2 58.28 Quite High
Inflammatory Pain 2 53.68 Quite High
Neuropathic Pain 2 52.80 Quite High
Fibromyalgia 44 50.00 Quite Low
Syndrome 2 38.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A subsequent study also found that subjects homozygous for the CAT haplotype had reduced levels of GCH1 mRNA as well as reduced levels of BH4 compared to subjects not carrying the haplotype [10].
Negative_regulation (reduced) of Localization (levels) of GCH1 associated with tetrahydrobiopterin and gch1
1) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759922 Disease Relevance 0.99 Pain Relevance 1.13
A subsequent study also found that subjects homozygous for the CAT haplotype had reduced levels of GCH1 mRNA as well as reduced levels of BH4 compared to subjects not carrying the haplotype [10].
Negative_regulation (reduced) of Localization (levels) of GCH1 associated with tetrahydrobiopterin and gch1
2) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759922 Disease Relevance 1.00 Pain Relevance 1.14

General Comments

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