INT283980

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Context Info
Confidence 0.24
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL12A, IL23A) extracellular space (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
Th17 cells 1
T-cell 1
IL12A (Homo sapiens)
IL23A (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 61 98.88 Very High Very High Very High
cytokine 19 96.56 Very High Very High Very High
chemokine 2 80.12 Quite High
Inflammation 15 79.24 Quite High
Arthritis 21 56.56 Quite High
depression 1 49.36 Quite Low
withdrawal 8 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 69 98.88 Very High Very High Very High
Autoimmune Disease 1 97.74 Very High Very High Very High
Malaria 163 87.80 High High
Infection 70 81.80 Quite High
INFLAMMATION 21 79.24 Quite High
Arthritis 2 56.56 Quite High
Cancer 2 55.96 Quite High
Heart Disease 1 55.64 Quite High
Affective Disorder 1 51.16 Quite High
Depression 1 49.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The new psoriasis model is explained by the interaction between epidermal keratinocytes and various immunocytes, including the four different CD4+ subsets: Th1, Th2, Th17, and T-regs.18 Recently discovered Th17 cells form part of a pathway mainly regulated by IL-23 (among several cytokines), and have been associated with regulation of autoimmunity.3 Although initial experiments were targeted towards IL-12’s p40 subunit, serendipitous findings suggested that IL-23 (which shares a common p40 subunit with IL-12) was more important in the psoriasis immunopathogenesis, shifting the paradigm to a Th1/Th17 hypothesis.19,20
IL-12 Binding (shares) of IL-23 in Th17 cells associated with psoriasis, autoimmune disease and cytokine
1) Confidence 0.24 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.95 Pain Relevance 0.48
Yet, embracing the complexity that constitutes the human immune milieu, the recognition of IL-12 and IL-23 in orchestrating the development of TH1 and TH17 subsets, respectively, pose new questions in T-cell decision making [reviewed in (84)].
IL-12 Binding (recognition) of IL-23 in T-cell
2) Confidence 0.03 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.37 Pain Relevance 0.08

General Comments

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