INT283996

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
Anatomy Link Frequency
blood 2
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 1 98.62 Very High Very High Very High
headache 6 98.34 Very High Very High Very High
Bioavailability 1 98.08 Very High Very High Very High
cytokine 14 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Antihistamine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 163 100.00 Very High Very High Very High
Low Back Pain 1 98.62 Very High Very High Very High
Headache 6 98.34 Very High Very High Very High
Infection 77 95.00 High High
Fatigue 3 94.14 High High
Immunodeficiency 4 50.00 Quite Low
Immunization 4 34.84 Quite Low
Agammaglobulinemia 10 22.88 Low Low
Disease 24 5.00 Very Low Very Low Very Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to an overall increase in total IgG antibody titres to most blood stage malaria antigen, the magnitude of in vitro growth-inhibitory antibody (GIA) activity decreased with age (children screened were 2–14 years old), even though GIA activity was significantly associated with less risk of malaria infection after adjusting for age (22,23).
Negative_regulation (decreased) of Positive_regulation (increase) of IgG in blood associated with malaria and infection
1) Confidence 0.20 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.76 Pain Relevance 0
A patient survey in 2008 by the Immune Deficiency Foundation reported that 68% of respondents noted fatigue and increased susceptibility to infections at the time of their trough nadir just prior to their next IVIg infusion.20 Clinicians have also attempted to correlate infusion related side effects such as headache and back pain to high peak serum IgG levels.21 In contrast, a lower systemic side effect profile has been consistently observed throughout many reports of subcutaneous replacement therapy, most likely related to the more stable physiologic IgG levels achieved.22
Negative_regulation (effect) of Positive_regulation (related) of IgG associated with fatigue, headache, infection and backache
2) Confidence 0.11 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.39 Pain Relevance 0.25

General Comments

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