INT284

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Context Info
Confidence 0.67
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 13.56
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (Ggt6)
Anatomy Link Frequency
liver 3
blood 1
bile duct 1
vessels 1
Ggt6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 9 99.76 Very High Very High Very High
headache 2 99.72 Very High Very High Very High
Bile 28 99.28 Very High Very High Very High
Paracetamol 6 98.72 Very High Very High Very High
fibrosis 7 98.60 Very High Very High Very High
Arthritis 12 98.48 Very High Very High Very High
abdominal pain 9 98.20 Very High Very High Very High
anesthesia 1 97.20 Very High Very High Very High
Inflammation 6 96.76 Very High Very High Very High
Bioavailability 2 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fever 4 99.90 Very High Very High Very High
Anaemia 3 99.90 Very High Very High Very High
Hyperbilirubinemia 1 99.88 Very High Very High Very High
Rheumatoid Arthritis 9 99.76 Very High Very High Very High
Headache 2 99.72 Very High Very High Very High
Vomiting 6 99.52 Very High Very High Very High
Thyroiditis 4 99.44 Very High Very High Very High
Jaundice 8 99.36 Very High Very High Very High
Appetite Loss 4 99.36 Very High Very High Very High
Stress 3 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UDC significantly decreased elevated gamma-glutamyl transferase and creatinine serum levels and induced some clinical improvements such as disappearance of headaches in four patients.
Positive_regulation (elevated) of gamma-glutamyl transferase associated with headache
1) Confidence 0.67 Published 2000 Journal Fundam Clin Pharmacol Section Abstract Doc Link 11206711 Disease Relevance 0.22 Pain Relevance 0.29
The main clinical features were anorexia, nausea, headache, pyrexia and elevated gamma-glutamyl transferase.
Positive_regulation (elevated) of gamma-glutamyl transferase associated with appetite loss, vomiting, headache and fever
2) Confidence 0.67 Published 1997 Journal Occup Med (Lond) Section Abstract Doc Link 9374073 Disease Relevance 0.83 Pain Relevance 0.10
The animal was icteric, had severe bilirubinemia, and elevated serum gamma glutamyl transferase concentrations.
Positive_regulation (elevated) of serum gamma glutamyl transferase associated with hyperbilirubinemia and jaundice
3) Confidence 0.47 Published 2003 Journal J. Wildl. Dis. Section Abstract Doc Link 14567238 Disease Relevance 0.51 Pain Relevance 0.10
The activities of marker enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and gamma glutamyl transferase) and bilirubin level in serum and the levels of cholesterol, triglycerides, and free fatty acids in both serum and liver were found to be increased when rats were challenged with APAP.
Positive_regulation (increased) of gamma glutamyl transferase in liver associated with paracetamol
4) Confidence 0.46 Published 2004 Journal J Med Food Section Abstract Doc Link 15298774 Disease Relevance 0.17 Pain Relevance 0.52
Oxidative stress in liver was accompanied by an increase in aspartate aminotransferase and gamma-glutamyl transferase in blood serum.
Positive_regulation (increase) of gamma-glutamyl transferase in blood associated with stress
5) Confidence 0.37 Published 2004 Journal Biomed Khim Section Abstract Doc Link 15628595 Disease Relevance 0.61 Pain Relevance 0.45
Abnormal haematological and biochemical findings included marked anaemia, neutrophilic leucocytosis, markedly elevated concentration of fibrinogen and mildly elevated gamma-glutamyl-transferase activity.
Positive_regulation (elevated) of gamma-glutamyl-transferase associated with anaemia
6) Confidence 0.26 Published 2004 Journal DTW. Dtsch. Tierarztl. Wochenschr. Section Abstract Doc Link 14983755 Disease Relevance 0.79 Pain Relevance 0.12
Serum procollagen-IV-peptide and gamma-glutamyl-transferase levels were increased in persons with severe periportal fibrosis, irregular liver texture of portofugal collateral vessels.
Positive_regulation (increased) of gamma-glutamyl-transferase in vessels associated with fibrosis
7) Confidence 0.26 Published 1997 Journal Trop. Med. Int. Health Section Abstract Doc Link 9491101 Disease Relevance 1.11 Pain Relevance 0.19
RESULTS: Upon termination of the study on day 4, serum gamma-glutamyl transferase activity and alkaline phosphatase/alanine aminotransferase ratios were significantly elevated in both high- and normal-dose cohorts compared with vehicle-treated animals.
Positive_regulation (elevated) of gamma-glutamyl transferase
8) Confidence 0.16 Published 2006 Journal Molecular diagnosis & therapy Section Body Doc Link 16771604 Disease Relevance 0 Pain Relevance 0
High levels of alkaline phosphatase and gamma-glutamyl transferase were detected.
Positive_regulation (levels) of gamma-glutamyl transferase
9) Confidence 0.11 Published 2002 Journal Inflamm. Bowel Dis. Section Abstract Doc Link 12131613 Disease Relevance 1.43 Pain Relevance 0.15
A concomitant increase in serum aminotransferases was found in 15% of patients with elevated gamma glutamyl transferase level.
Positive_regulation (elevated) of gamma glutamyl transferase
10) Confidence 0.09 Published 1980 Journal Scand. J. Rheumatol. Section Abstract Doc Link 7433928 Disease Relevance 1.05 Pain Relevance 0.39
Values for alkaline phosphatase, bilirubin, gamma-glutamyl transferase, sorbitol dehydrogenase, and bromsulpthalein half-life were increased and bilirubinuria was evident before surgery.
Positive_regulation (Values) of gamma-glutamyl transferase
11) Confidence 0.08 Published 1985 Journal J. Am. Vet. Med. Assoc. Section Abstract Doc Link 4019295 Disease Relevance 0.88 Pain Relevance 0.18
Alanine aminotransferase levels were significantly higher (p=0.05) in patients with bile duct stones than in those without, but also alkaline phosphatase (p=0.07), gamma-glutamyl transferase (p=0.09) and bilirubin (p=0.09) levels seemed to be higher in patients with bile duct stones than in those without, although the differences in these values did not reach statistical significance.
Positive_regulation (higher) of gamma-glutamyl transferase in bile duct associated with bile
12) Confidence 0.08 Published 2001 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 11256798 Disease Relevance 0.66 Pain Relevance 0.81
In 183 in-patients with rheumatoid arthritis, the serum gamma glutamyl transferase level was elevated in 47% and serum alkaline phosphatase (of liver origin) in 24%.
Positive_regulation (elevated) of gamma glutamyl transferase in liver associated with rheumatoid arthritis
13) Confidence 0.08 Published 1980 Journal Scand. J. Rheumatol. Section Abstract Doc Link 7433928 Disease Relevance 0.79 Pain Relevance 0.34
The frequently occurring isolated increase of serum gamma glutamyl transferase and/or serum alkaline phosphatase in arthritis may be an unspecific reaction to inflammation.
Positive_regulation (increase) of gamma glutamyl transferase associated with inflammation and arthritis
14) Confidence 0.08 Published 1980 Journal Scand. J. Rheumatol. Section Abstract Doc Link 7433928 Disease Relevance 1.20 Pain Relevance 0.48
This condition was associated with anaemia and elevation of alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase.
Positive_regulation (elevation) of gamma-glutamyl transferase associated with anaemia
15) Confidence 0.07 Published 2009 Journal J Small Anim Pract Section Abstract Doc Link 19527423 Disease Relevance 0.67 Pain Relevance 0.10
All dogs except one had serum elevation of total bilirubin and/or alkaline phosphatase, alanine aminotransferase and gamma glutamyl transferase.
Positive_regulation (elevation) of gamma glutamyl transferase
16) Confidence 0.07 Published 2000 Journal Vet Radiol Ultrasound Section Abstract Doc Link 10850878 Disease Relevance 0.79 Pain Relevance 0.25
Concomitant elevation of the serum gamma-glutamyl transferase suggested that the alkaline phosphatase was of hepatic origin.
Positive_regulation (elevation) of gamma-glutamyl transferase
17) Confidence 0.05 Published 1978 Journal Ann. Intern. Med. Section Abstract Doc Link 25034 Disease Relevance 0.35 Pain Relevance 0.07
A cholestatic picture was suggested on liver function assay, with her alkaline phosphatase and gamma-glutamyl transferase elevated at 142 units/L and 78 units/L respectively.
Positive_regulation (elevated) of gamma-glutamyl transferase in liver
18) Confidence 0.01 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2944189 Disease Relevance 1.50 Pain Relevance 0.07

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