INT28402

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.51
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MME) plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
bladder 2
MME (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 7 99.80 Very High Very High Very High
narcan 3 99.76 Very High Very High Very High
Bile 1 58.00 Quite High
metalloproteinase 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
bradykinin 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cholecystitis 2 100.00 Very High Very High Very High
Gallbladder Disease 7 97.04 Very High Very High Very High
Cancer 127 94.64 High High
Renal Cancer 78 89.00 High High
Malignant Neoplastic Disease 10 16.88 Low Low
Metastasis 2 8.56 Low Low
Carcinoma 6 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Aggression 4 5.00 Very Low Very Low Very Low
Leukemia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With respect to protein expression, DPP IV and NEP were down-regulated in ChRCC and RO, whereas CCRCC showed a moderate to strong immunostaining.
Negative_regulation (-) of Negative_regulation (regulated) of NEP
1) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.45 Pain Relevance 0
With respect to protein expression, DPP IV and NEP were down-regulated in ChRCC and RO, whereas CCRCC showed a moderate to strong immunostaining.
Negative_regulation (regulated) of Negative_regulation (-) of NEP
2) Confidence 0.43 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.45 Pain Relevance 0
Naloxone-reversible inhibition of gall-bladder mucosal fluid secretion in experimental cholecystitis in the cat by acetorphan, an enkephalinase inhibitor.
Negative_regulation (inhibition) of Negative_regulation (inhibitor) of enkephalinase in bladder associated with narcan and cholecystitis
3) Confidence 0.42 Published 1989 Journal Clin. Sci. Section Title Doc Link 2758762 Disease Relevance 0.61 Pain Relevance 0.57
The majority of the vertebrate M13 peptidases delineate into functionally related clusters representing the PHEX, Kell, ECE-1, ECE-2, ECEL1, neprilysin and MMELLII groups of peptidases (Figure 2 I-V).
Negative_regulation (representing) of Negative_regulation (groups) of neprilysin
4) Confidence 0.04 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0 Pain Relevance 0

General Comments

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