INT284088

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.40
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NTRK2) extracellular region (BDNF) plasma membrane (NTRK2)
cytoplasmic membrane-bounded vesicle (BDNF)
BDNF (Homo sapiens)
NTRK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 84 100.00 Very High Very High Very High
depression 5 91.00 High High
long-term potentiation 4 85.40 High High
Migraine 4 72.16 Quite High
Inflammatory response 4 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 505 99.24 Very High Very High Very High
Death 5 94.16 High High
Diabetes Mellitus 60 94.08 High High
Depression 5 91.00 High High
Stress 60 86.76 High High
Cardiovascular Disease 132 77.28 Quite High
Headache 4 72.16 Quite High
Aging 44 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 24 5.00 Very Low Very Low Very Low
Stroke 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neurotrophic tyrosine kinase receptor type 2 (NTRK2/TrkB) is a receptor for BDNF [43].
BDNF Binding (receptor) of TrkB associated with bdmf
1) Confidence 0.41 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.62 Pain Relevance 0.55
The neurotrophic tyrosine kinase receptor type 2 (NTRK2/TrkB) is a receptor for BDNF [43].
BDNF Binding (receptor) of kinase receptor type 2 associated with bdmf
2) Confidence 0.36 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.62 Pain Relevance 0.56
However, TrkB is downregulated following the binding of BDNF [45].
BDNF Binding (binding) of TrkB associated with bdmf
3) Confidence 0.35 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.81 Pain Relevance 0.60
Therefore, due to an increased level of PAI-1, mature BDNF could not be produced, which in turn could not bind to TrkB.
BDNF Neg (not) Binding (bind) of TrkB associated with bdmf
4) Confidence 0.30 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.73 Pain Relevance 0.61
While proBDNF binds only to p75 receptor, mature BDNF displays high affinity to TrkB and lower affinity to p75 [61].
BDNF Binding (affinity) of TrkB
5) Confidence 0.04 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.62 Pain Relevance 0.04

General Comments

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